Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by ANI Pharmaceuticals, Inc., priced at $0.7570 per EA under NDC 70954053120. Its NADAC has been published 152 times since Nov 8, 2023.
FDA first approved this application on Aug 24, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
ANI Pharmaceuticals, Inc.NDC
70954053120
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA217610FDA Approved
8/24/2023
TE Code
AB
On Market Since
8/24/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 152 times since Nov 8, 2023, and over the history we have for it it has declined 77.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7570 per EA |
|---|---|
| All-time high | $3.7861 (Apr 10, 2024) |
| All-time low | $0.7570 (Sep 23, 2026) |
| 52-week high | $1.9622 |
| 52-week low | $0.7570 |
| Median price | $1.7464 |
| Average price | $1.9892 |
| Largest weekly change | +54.8% (Sep 18, 2024) |
| Weeks tracked | 152 |
| Tracking since | Nov 8, 2023 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
ANI Pharmaceuticals, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Estradiol market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by ANI Pharmaceuticals, Inc., is $0.7570 per EA (NDC 70954053120), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 77.8%. It has been tracked across 152 weekly CMS publications since Nov 8, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Nov 8, 2023, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $0.7570 (Sep 23, 2026) to a high of $3.7861 (Apr 10, 2024), with a median of $1.7464 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (0.25 MG) GEL PK in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 70954053120) is labeled by ANI Pharmaceuticals, Inc., and CMS classifies it as a generic product.