Product Information
ADAPALENE 0.3% GEL is a generic product labeled by Encube Ethicals, Inc., priced at $0.5038 per GM under NDC 21922005106. Its NADAC has been published 174 times since Jun 7, 2023.
FDA first approved this application on Jun 14, 2012. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
3 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922005106
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ADAPALENEApproval Type
Generic (ANDA)
FDA Application
ANDA200298FDA Approved
6/14/2012
TE Code
AB
On Market Since
8/7/2023
Pharmacological Classes
Price Statistics
The NADAC for ADAPALENE 0.3% GEL has been published 174 times since Jun 7, 2023, and over the history we have for it it has declined 34.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5038 per GM |
|---|---|
| All-time high | $0.9951 (Sep 13, 2023) |
| All-time low | $0.4880 (Feb 18, 2026) |
| 52-week high | $0.5574 |
| 52-week low | $0.4880 |
| Median price | $0.5835 |
| Average price | $0.6058 |
| Largest weekly change | +37.3% (Aug 23, 2023) |
| Weeks tracked | 174 |
| Tracking since | Jun 7, 2023 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Adapalene Gel USP, 0.3% market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ADAPALENE 0.3% GEL?
The current National Average Drug Acquisition Cost (NADAC) for ADAPALENE 0.3% GEL, manufactured by Encube Ethicals, Inc., is $0.5038 per GM (NDC 21922005106), effective Sep 30, 2026.
How has the price of ADAPALENE 0.3% GEL changed over time?
Over the history we have for it, the NADAC for ADAPALENE 0.3% GEL has declined 34.8%. It has been tracked across 174 weekly CMS publications since Jun 7, 2023.
What are the highest and lowest recorded NADAC prices for ADAPALENE 0.3% GEL?
Since Jun 7, 2023, the NADAC for ADAPALENE 0.3% GEL has ranged from a low of $0.4880 (Feb 18, 2026) to a high of $0.9951 (Sep 13, 2023), with a median of $0.5835 per GM.
Are there cheaper alternatives to ADAPALENE 0.3% GEL?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ADAPALENE 0.3% GEL in a comparable dosage form, but none are currently priced below it.
Who manufactures ADAPALENE 0.3% GEL?
ADAPALENE 0.3% GEL (NDC 21922005106) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.