Product Information
BUPROPION HCL XL 300 MG TABLET is a generic product labeled by Epic Pharma LLC, priced at $0.1004 per EA under NDC 42806041605. Its NADAC has been published 164 times since Aug 16, 2023.
FDA first approved this application on Jun 14, 2018. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
300 mg/1
Manufacturer
Epic Pharma LLCNDC
42806041605
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA210015FDA Approved
6/14/2018
TE Code
AB3
On Market Since
4/30/2023
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL XL 300 MG TABLET has been published 164 times since Aug 16, 2023, and over the history we have for it it has declined 43.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1004 per EA |
|---|---|
| All-time high | $0.1988 (Feb 14, 2024) |
| All-time low | $0.1004 (Sep 23, 2026) |
| 52-week high | $0.1461 |
| 52-week low | $0.1004 |
| Median price | $0.1461 |
| Average price | $0.1440 |
| Largest weekly change | -27.4% (Feb 21, 2024) |
| Weeks tracked | 164 |
| Tracking since | Aug 16, 2023 |
Generic Alternatives
The matcher finds 9 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
bupropion hydrochloride market comparison
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Therapeutic class
Aminoketone class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPROPION HCL XL 300 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL XL 300 MG TABLET, manufactured by Epic Pharma LLC, is $0.1004 per EA (NDC 42806041605), effective Sep 30, 2026.
How has the price of BUPROPION HCL XL 300 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL XL 300 MG TABLET has declined 43.6%. It has been tracked across 164 weekly CMS publications since Aug 16, 2023.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL XL 300 MG TABLET?
Since Aug 16, 2023, the NADAC for BUPROPION HCL XL 300 MG TABLET has ranged from a low of $0.1004 (Sep 23, 2026) to a high of $0.1988 (Feb 14, 2024), with a median of $0.1461 per EA.
Are there cheaper alternatives to BUPROPION HCL XL 300 MG TABLET?
9 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL XL 300 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL XL 300 MG TABLET?
BUPROPION HCL XL 300 MG TABLET (NDC 42806041605) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.