Product Information
ESTRADIOL 0.1% (0.75 MG) GEL PK is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $0.7544 per EA under NDC 45802031030. Its NADAC has been published 133 times since Feb 7, 2024.
FDA first approved this application on Nov 14, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.75 mg/.75g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802031030
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216524FDA Approved
11/14/2023
TE Code
AB
On Market Since
12/7/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.75 MG) GEL PK has been published 133 times since Feb 7, 2024, and over the history we have for it it has declined 79.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7544 per EA |
|---|---|
| All-time high | $3.6639 (May 15, 2024) |
| All-time low | $0.7544 (Aug 19, 2026) |
| 52-week high | $2.1540 |
| 52-week low | $0.7544 |
| Median price | $1.9275 |
| Average price | $2.0400 |
| Largest weekly change | -44.9% (May 22, 2024) |
| Weeks tracked | 133 |
| Tracking since | Feb 7, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.75 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.75 MG) GEL PK, manufactured by Padagis Israel Pharmaceuticals Ltd, is $0.7544 per EA (NDC 45802031030), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.1% (0.75 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.75 MG) GEL PK has declined 79.2%. It has been tracked across 133 weekly CMS publications since Feb 7, 2024.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.75 MG) GEL PK?
Since Feb 7, 2024, the NADAC for ESTRADIOL 0.1% (0.75 MG) GEL PK has ranged from a low of $0.7544 (Aug 19, 2026) to a high of $3.6639 (May 15, 2024), with a median of $1.9275 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.75 MG) GEL PK?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (0.75 MG) GEL PK in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.75 MG) GEL PK?
ESTRADIOL 0.1% (0.75 MG) GEL PK (NDC 45802031030) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.