Product Information
ESTRADIOL 0.1% (1 MG) GEL PKT is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $0.9673 per GM under NDC 45802045230. Its NADAC has been published 139 times since Feb 7, 2024.
FDA first approved this application on Nov 14, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802045230
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216524FDA Approved
11/14/2023
TE Code
AB
On Market Since
12/7/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has been published 139 times since Feb 7, 2024, and over the history we have for it it has declined 73.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9673 per GM |
|---|---|
| All-time high | $3.6929 (Mar 13, 2024) |
| All-time low | $0.9673 (Sep 23, 2026) |
| 52-week high | $1.9348 |
| 52-week low | $0.9673 |
| Median price | $1.8695 |
| Average price | $1.9854 |
| Largest weekly change | -55.7% (Apr 17, 2024) |
| Weeks tracked | 139 |
| Tracking since | Feb 7, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
estradiol market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1 MG) GEL PKT, manufactured by Padagis Israel Pharmaceuticals Ltd, is $0.9673 per GM (NDC 45802045230), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (1 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has declined 73.8%. It has been tracked across 139 weekly CMS publications since Feb 7, 2024.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1 MG) GEL PKT?
Since Feb 7, 2024, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has ranged from a low of $0.9673 (Sep 23, 2026) to a high of $3.6929 (Mar 13, 2024), with a median of $1.8695 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1 MG) GEL PKT?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (1 MG) GEL PKT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (1 MG) GEL PKT?
ESTRADIOL 0.1% (1 MG) GEL PKT (NDC 45802045230) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.