Product Information
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET is a generic product labeled by AvPAK, priced at $0.1223 per EA under NDC 50268055313. Its NADAC has been published 186 times since Mar 15, 2023.
FDA first approved this application on Oct 31, 2018. Its Orange Book therapeutic-equivalence code is AA.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET
Butalbital, Acetaminophen, and CaffeineStrength
325; 50; 40 mg/1; mg/1; mg/1
Manufacturer
AvPAKNDC
50268055313
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHEN; BUTALBITAL; CAFFEINEApproval Type
Generic (ANDA)
FDA Application
ANDA209587FDA Approved
10/31/2018
TE Code
AA
On Market Since
8/11/2022
Pharmacological Classes
Price Statistics
The NADAC for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET has been published 186 times since Mar 15, 2023, and over the history we have for it it has declined 17.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1223 per EA |
|---|---|
| All-time high | $0.1664 (Oct 16, 2024) |
| All-time low | $0.1112 (Nov 20, 2024) |
| 52-week high | $0.1398 |
| 52-week low | $0.1218 |
| Median price | $0.1447 |
| Average price | $0.1426 |
| Largest weekly change | +35.2% (Aug 21, 2024) |
| Weeks tracked | 186 |
| Tracking since | Mar 15, 2023 |
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
AvPAK manufacturer profile
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Drug market
Butalbital, Acetaminophen, and Caffeine market comparison
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Therapeutic class
Barbiturate class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET, manufactured by AvPAK, is $0.1223 per EA (NDC 50268055313), effective Sep 30, 2026.
How has the price of BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET has declined 17.2%. It has been tracked across 186 weekly CMS publications since Mar 15, 2023.
What are the highest and lowest recorded NADAC prices for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET?
Since Mar 15, 2023, the NADAC for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET has ranged from a low of $0.1112 (Nov 20, 2024) to a high of $0.1664 (Oct 16, 2024), with a median of $0.1447 per EA.
Are there cheaper alternatives to BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET?
6 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET?
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET (NDC 50268055313) is labeled by AvPAK, and CMS classifies it as a generic product.