Product Information
ISOTRETINOIN 40 MG CAPSULE is a generic product labeled by Aurobindo Pharma Limited, priced at $6.7472 per EA under NDC 59651063603. Its NADAC has been published 90 times since Dec 4, 2024.
FDA first approved this application on Jan 29, 2024. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/1
Manufacturer
Aurobindo Pharma LimitedNDC
59651063603
Classification
Generic
Dosage Form
CAPSULE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ISOTRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA218194FDA Approved
1/29/2024
TE Code
AB2
On Market Since
1/29/2024
Pharmacological Classes
Price Statistics
The NADAC for ISOTRETINOIN 40 MG CAPSULE has been published 90 times since Dec 4, 2024, and over the history we have for it it has declined 59.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $6.7472 per EA |
|---|---|
| All-time high | $16.8560 (Jan 15, 2025) |
| All-time low | $5.0999 (May 20, 2026) |
| 52-week high | $15.9249 |
| 52-week low | $5.0999 |
| Median price | $13.4408 |
| Average price | $12.0092 |
| Largest weekly change | -23.2% (Feb 18, 2026) |
| Weeks tracked | 90 |
| Tracking since | Dec 4, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 68% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ISOTRETINOIN 40 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for ISOTRETINOIN 40 MG CAPSULE, manufactured by Aurobindo Pharma Limited, is $6.7472 per EA (NDC 59651063603), effective Aug 19, 2026.
How has the price of ISOTRETINOIN 40 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for ISOTRETINOIN 40 MG CAPSULE has declined 59.6%. It has been tracked across 90 weekly CMS publications since Dec 4, 2024.
What are the highest and lowest recorded NADAC prices for ISOTRETINOIN 40 MG CAPSULE?
Since Dec 4, 2024, the NADAC for ISOTRETINOIN 40 MG CAPSULE has ranged from a low of $5.0999 (May 20, 2026) to a high of $16.8560 (Jan 15, 2025), with a median of $13.4408 per EA.
Are there cheaper alternatives to ISOTRETINOIN 40 MG CAPSULE?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ZENATANE 40 MG CAPSULE, is $2.1849 per EA — about 68% below ISOTRETINOIN 40 MG CAPSULE.
Who manufactures ISOTRETINOIN 40 MG CAPSULE?
ISOTRETINOIN 40 MG CAPSULE (NDC 59651063603) is labeled by Aurobindo Pharma Limited, and CMS classifies it as a generic product.