Product Information
ADAPALENE 0.3% GEL is a generic product labeled by Mayne Pharma, priced at $0.5038 per GM under NDC 68308066625. Its NADAC has been published 130 times since Apr 10, 2024.
FDA first approved this application on Jun 19, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
3 mg/g
Manufacturer
Mayne PharmaNDC
68308066625
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ADAPALENEApproval Type
Authorized Generic (NDA)
FDA Application
NDA021753FDA Approved
6/19/2007
TE Code
AB
On Market Since
2/26/2024
Pharmacological Classes
Price Statistics
The NADAC for ADAPALENE 0.3% GEL has been published 130 times since Apr 10, 2024, and over the history we have for it it has declined 29.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5038 per GM |
|---|---|
| All-time high | $0.7191 (Apr 10, 2024) |
| All-time low | $0.4880 (Feb 18, 2026) |
| 52-week high | $0.5574 |
| 52-week low | $0.4880 |
| Median price | $0.5362 |
| Average price | $0.5527 |
| Largest weekly change | -29.5% (Apr 17, 2024) |
| Weeks tracked | 130 |
| Tracking since | Apr 10, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mayne Pharma manufacturer profile
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Drug market
ADAPALENE market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ADAPALENE 0.3% GEL?
The current National Average Drug Acquisition Cost (NADAC) for ADAPALENE 0.3% GEL, manufactured by Mayne Pharma, is $0.5038 per GM (NDC 68308066625), effective Sep 30, 2026.
How has the price of ADAPALENE 0.3% GEL changed over time?
Over the history we have for it, the NADAC for ADAPALENE 0.3% GEL has declined 29.9%. It has been tracked across 130 weekly CMS publications since Apr 10, 2024.
What are the highest and lowest recorded NADAC prices for ADAPALENE 0.3% GEL?
Since Apr 10, 2024, the NADAC for ADAPALENE 0.3% GEL has ranged from a low of $0.4880 (Feb 18, 2026) to a high of $0.7191 (Apr 10, 2024), with a median of $0.5362 per GM.
Are there cheaper alternatives to ADAPALENE 0.3% GEL?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ADAPALENE 0.3% GEL in a comparable dosage form, but none are currently priced below it.
Who manufactures ADAPALENE 0.3% GEL?
ADAPALENE 0.3% GEL (NDC 68308066625) is labeled by Mayne Pharma, and CMS classifies it as a generic product.