Product Information
TRETINOIN 0.025% CREAM is a generic product labeled by Actavis Pharma, Inc., priced at $0.4593 per GM under NDC 00472011745. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Jan 14, 1997. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/g
Manufacturer
Actavis Pharma, Inc.NDC
00472011745
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Authorized Generic (NDA)
FDA Application
NDA020404FDA Approved
1/14/1997
TE Code
AB
On Market Since
4/20/1998
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.025% CREAM has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 17.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4593 per GM |
|---|---|
| All-time high | $3.4357 (Aug 13, 2014) |
| All-time low | $0.4593 (Sep 23, 2026) |
| 52-week high | $0.9756 |
| 52-week low | $0.4593 |
| Median price | $1.7988 |
| Average price | $1.8578 |
| Largest weekly change | +195.6% (Apr 30, 2014) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Actavis Pharma, Inc. manufacturer profile
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Drug market
Tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.025% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.025% CREAM, manufactured by Actavis Pharma, Inc., is $0.4593 per GM (NDC 00472011745), effective Sep 30, 2026.
How has the price of TRETINOIN 0.025% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.025% CREAM has declined 17.6%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.025% CREAM?
Since Nov 28, 2013, the NADAC for TRETINOIN 0.025% CREAM has ranged from a low of $0.4593 (Sep 23, 2026) to a high of $3.4357 (Aug 13, 2014), with a median of $1.7988 per GM.
Are there cheaper alternatives to TRETINOIN 0.025% CREAM?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as TRETINOIN 0.025% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures TRETINOIN 0.025% CREAM?
TRETINOIN 0.025% CREAM (NDC 00472011745) is labeled by Actavis Pharma, Inc., and CMS classifies it as a generic product.