Lactulose

36 NDCs across 10 manufacturers|34 Generic,2 Brand

Lactulose is used to treat constipation and hepatic encephalopathy, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved before 1982, and the first generic was approved Jul 26, 1988. In 2024, Medicare Part D spent $75 million on Lactulose across 2.0 million claims for 723,000 beneficiaries.

Lactulose is available as 36 NDCs from 10 manufacturers (34 generic, 2 brand), with NADAC prices from $0.01 to $0.05 per ML — the most expensive product costs about 4.1× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

34G / 2B

Manufacturers

competing in market

Price Spread

$0.01 – $0.05

per ML, 28 of 36 NDCs

7d Activity

10↑20↓6 flat

avg -0.8% WoW · of 36 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

10 manufacturers producing LACTULOSE

Apozeal Pharmaceuticals Inc.

5 NDCs

$0.0175

avg/unit

Xttrium Laboratories, Inc.

Cumberland Pharmaceuticals Inc.

Cumberland Assured Products Inc.

2 NDCs

$8.2558

avg/unit

Sun Pharmaceutical Industries Inc.

1 NDC

$0.0224

avg/unit

Drug Portfolio

36 NDCs total, 36 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
KRISTALOSE 20 GM PACKET	66220072930	Cumberland Pharmaceuticals Inc.	$9.9154 per EA	—	—	—	Osmotic Laxative
KRISTALOSE 10 GM PACKET	66220071930	Cumberland Pharmaceuticals Inc.	$9.5808 per EA	—	—	+0.01%	Osmotic Laxative
LACTULOSE 20 GM PACKET	00121193030	PAI Holdings LLC	$8.3407 per EA	—	Generic	+1.83%	Osmotic Laxative
LACTULOSE 20 GM PACKET	73352090515	Trifluent Pharma LLC	$8.3407 per EA	—	Generic	+1.83%	Osmotic Laxative
LACTULOSE 20 GM PACKET	85592082930	Cumberland Assured Products Inc.	$8.3407 per EA	—	Generic	+1.83%	Osmotic Laxative
LACTULOSE 10 GM PACKET	85592081930	Cumberland Assured Products Inc.	$8.1709 per EA	—	Generic	+2.05%	Osmotic Laxative
LACTULOSE 10 GM PACKET	73352090015	Trifluent Pharma LLC	$8.1709 per EA	—	Generic	+2.05%	Osmotic Laxative
LACTULOSE 10 GM PACKET	00121096530	PAI Holdings LLC	$8.1709 per EA	—	Generic	+2.05%	Osmotic Laxative
LACTULOSE 20 GM/30 ML SOLUTION CUP	00121115440	PAI Holdings LLC	$0.0512 per ML	—	Generic	—	Osmotic Laxative
LACTULOSE 20 GM/30 ML SOLUTION CUP	00121115400	PAI Holdings LLC	$0.0493 per ML	—	Generic	—	Osmotic Laxative
LACTULOSE 20 GM/30 ML SOLUTION CUP	00116400511	Xttrium Laboratories, Inc.	$0.0493 per ML	—	Generic	—	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00527512070	Lannett Company Inc.	$0.0236 per ML	—	Generic	—	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	51672424309	Sun Pharmaceutical Industries Inc.	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00527512570	Lannett Company Inc.	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	62135000247	Chartwell RX LLC	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	83745040516	Apozeal Pharmaceuticals Inc.	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00121087316	PAI Holdings LLC	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	62135000347	Chartwell RX LLC	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00116400516	Xttrium Laboratories, Inc.	$0.0224 per ML	—	Generic	-1.02%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00116400508	Xttrium Laboratories, Inc.	$0.0199 per ML	—	Generic	-3.68%	Osmotic Laxative
CONSTULOSE 10 GM/15 ML SOLN	45963043963	Actavis Pharma, Inc.	$0.0199 per ML	—	Generic	-3.68%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	62135000237	Chartwell RX LLC	$0.0199 per ML	—	Generic	-3.68%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	62135000337	Chartwell RX LLC	$0.0199 per ML	—	Generic	-3.68%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	83745040508	Apozeal Pharmaceuticals Inc.	$0.0199 per ML	—	Generic	-3.68%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00116400532	Xttrium Laboratories, Inc.	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00121087332	PAI Holdings LLC	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00527512578	Lannett Company Inc.	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	83745040532	Apozeal Pharmaceuticals Inc.	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	62135000394	Chartwell RX LLC	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	62135000294	Chartwell RX LLC	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
CONSTULOSE 10 GM/15 ML SOLN	45963043965	Actavis Pharma, Inc.	$0.0196 per ML	—	Generic	-1.46%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	83745024916	Apozeal Pharmaceuticals Inc.	$0.0132 per ML	—	Generic	+0.53%	Osmotic Laxative
GENERLAC 10 GM/15 ML SOLUTION	62135089247	Chartwell RX LLC	$0.0132 per ML	—	Generic	+0.53%	Osmotic Laxative
ENULOSE 10 GM/15 ML SOLUTION	45963043864	Actavis Pharma, Inc.	$0.0132 per ML	—	Generic	+0.53%	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	00527512078	Lannett Company Inc.	$0.0131 per ML	—	Generic	—	Osmotic Laxative
LACTULOSE 10 GM/15 ML SOLUTION	83745024932	Apozeal Pharmaceuticals Inc.	$0.0126 per ML	—	Generic	-1.95%	Osmotic Laxative

Frequently Asked Questions

What is Lactulose used to treat?

Lactulose is used to treat constipation and hepatic encephalopathy, per the National Library of Medicine's MED-RT classification.

When did Lactulose become available as a generic?

FDA approved the first generic Lactulose (ANDA) on Jul 26, 1988.

How much does Medicare spend on Lactulose?

In 2024, Medicare Part D spent $75 million on Lactulose across 2.0 million claims for 723,000 beneficiaries.

How many Lactulose products are on the market?

The Lactulose drug market contains 36 NDCs from 10 manufacturers — 34 generic and 2 brand products.

What is the price range for Lactulose?

NADAC reference prices for Lactulose range from $0.0126 to $0.0512 per ML — the most expensive product costs about 4.1× the cheapest. 8 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Which manufacturers make Lactulose?

10 manufacturers list Lactulose in NADAC. Ranked by number of NDCs, the largest are Chartwell RX LLC (7), PAI Holdings LLC (6), Apozeal Pharmaceuticals Inc. (5), Xttrium Laboratories, Inc. (4), Lannett Company Inc. (4).

How has the price of Lactulose changed recently?

Over the past 7 days, 10 Lactulose NDCs rose and 20 fell, with a market-wide average change of -0.8%.