This NDC is on FDA's drug shortage list (posted Mar 13, 2023)
Product Information
METHOTREXATE 50 MG/2 ML VIAL is a generic product labeled by Hikma Pharmaceuticals USA Inc., priced at $1.2379 per ML under NDC 00143951910. Its NADAC has been published 220 times since Apr 11, 2018.
FDA first approved this application on Sep 16, 1986. Its Orange Book therapeutic-equivalence code is AP.
Strength
25 mg/mL
Manufacturer
Hikma Pharmaceuticals USA Inc.NDC
00143951910
Classification
Generic
Dosage Form
SOLUTION
Route
INTRA-ARTERIAL; INTRAMUSCULAR; INTRATHECAL; INTRAVENOUS
Effective Date
8/19/2026
Active Ingredients
METHOTREXATEApproval Type
Generic (ANDA)
FDA Application
ANDA089340FDA Approved
9/16/1986
TE Code
AP
On Market Since
10/10/2017
Pharmacological Classes
Price Statistics
The NADAC for METHOTREXATE 50 MG/2 ML VIAL has been published 220 times since Apr 11, 2018, and over the history we have for it it has declined 27.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.2379 per ML |
|---|---|
| All-time high | $1.7314 (Jul 11, 2018) |
| All-time low | $1.1511 (Jan 17, 2024) |
| 52-week high | $1.3431 |
| 52-week low | $1.2060 |
| Median price | $1.3518 |
| Average price | $1.3671 |
| Largest weekly change | +14.9% (Feb 21, 2024) |
| Weeks tracked | 220 |
| Tracking since | Apr 11, 2018 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Methotrexate market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHOTREXATE 50 MG/2 ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for METHOTREXATE 50 MG/2 ML VIAL, manufactured by Hikma Pharmaceuticals USA Inc., is $1.2379 per ML (NDC 00143951910), effective Aug 19, 2026.
How has the price of METHOTREXATE 50 MG/2 ML VIAL changed over time?
Over the history we have for it, the NADAC for METHOTREXATE 50 MG/2 ML VIAL has declined 27.9%. It has been tracked across 220 weekly CMS publications since Apr 11, 2018.
What are the highest and lowest recorded NADAC prices for METHOTREXATE 50 MG/2 ML VIAL?
Since Apr 11, 2018, the NADAC for METHOTREXATE 50 MG/2 ML VIAL has ranged from a low of $1.1511 (Jan 17, 2024) to a high of $1.7314 (Jul 11, 2018), with a median of $1.3518 per ML.
Are there cheaper alternatives to METHOTREXATE 50 MG/2 ML VIAL?
No other NADAC-published product currently shares the active ingredient and strength of METHOTREXATE 50 MG/2 ML VIAL in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures METHOTREXATE 50 MG/2 ML VIAL?
METHOTREXATE 50 MG/2 ML VIAL (NDC 00143951910) is labeled by Hikma Pharmaceuticals USA Inc., and CMS classifies it as a generic product.
Is METHOTREXATE 50 MG/2 ML VIAL in shortage?
Yes — NDC 00143951910 is currently listed in FDA's drug shortage database (posted Mar 13, 2023).