Product Information
ESTRADIOL 0.075 MG PATCH(1/WK) is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $13.0588 per EA under NDC 00378335199. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Feb 24, 2000. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.075 mg/d
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378335199
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA075182FDA Approved
2/24/2000
TE Code
AB2
On Market Since
4/7/2005
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.075 MG PATCH(1/WK) has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 11.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $13.0588 per EA |
|---|---|
| All-time high | $17.8301 (Jul 16, 2014) |
| All-time low | $9.6410 (May 22, 2024) |
| 52-week high | $14.6188 |
| 52-week low | $11.9422 |
| Median price | $14.0441 |
| Average price | $14.0414 |
| Largest weekly change | +29.6% (Aug 21, 2024) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 38% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.075 MG PATCH(1/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.075 MG PATCH(1/WK), manufactured by Mylan Pharmaceuticals Inc., is $13.0588 per EA (NDC 00378335199), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.075 MG PATCH(1/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.075 MG PATCH(1/WK) has risen 11.7%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.075 MG PATCH(1/WK)?
Since Nov 28, 2013, the NADAC for ESTRADIOL 0.075 MG PATCH(1/WK) has ranged from a low of $9.6410 (May 22, 2024) to a high of $17.8301 (Jul 16, 2014), with a median of $14.0441 per EA.
Are there cheaper alternatives to ESTRADIOL 0.075 MG PATCH(1/WK)?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ESTRADIOL 0.075 MG PATCH(2/WK), is $8.1128 per EA — about 38% below ESTRADIOL 0.075 MG PATCH(1/WK).
Who manufactures ESTRADIOL 0.075 MG PATCH(1/WK)?
ESTRADIOL 0.075 MG PATCH(1/WK) (NDC 00378335199) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.