Product Information
ESTRADIOL 0.075 MG PATCH(2/WK) is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $8.1128 per EA under NDC 00378462226. Its NADAC has been published 405 times since Jan 2, 2019.
FDA first approved this application on Aug 15, 2018. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.075 mg/d
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378462226
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA206685FDA Approved
8/15/2018
TE Code
AB3
On Market Since
11/1/2018
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.075 MG PATCH(2/WK) has been published 405 times since Jan 2, 2019, and over the history we have for it it has risen 3.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.1128 per EA |
|---|---|
| All-time high | $9.3768 (Mar 10, 2021) |
| All-time low | $5.2541 (May 22, 2024) |
| 52-week high | $8.1128 |
| 52-week low | $6.8560 |
| Median price | $7.2315 |
| Average price | $7.2807 |
| Largest weekly change | +31.0% (Jun 19, 2024) |
| Weeks tracked | 405 |
| Tracking since | Jan 2, 2019 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.075 MG PATCH(2/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.075 MG PATCH(2/WK), manufactured by Mylan Pharmaceuticals Inc., is $8.1128 per EA (NDC 00378462226), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.075 MG PATCH(2/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.075 MG PATCH(2/WK) has risen 3.1%. It has been tracked across 405 weekly CMS publications since Jan 2, 2019.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.075 MG PATCH(2/WK)?
Since Jan 2, 2019, the NADAC for ESTRADIOL 0.075 MG PATCH(2/WK) has ranged from a low of $5.2541 (May 22, 2024) to a high of $9.3768 (Mar 10, 2021), with a median of $7.2315 per EA.
Are there cheaper alternatives to ESTRADIOL 0.075 MG PATCH(2/WK)?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.075 MG PATCH(2/WK) in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.075 MG PATCH(2/WK)?
ESTRADIOL 0.075 MG PATCH(2/WK) (NDC 00378462226) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.