Product Information
ISOTRETINOIN 25 MG CAPSULE is a generic product labeled by Actavis Pharma, Inc., priced at $10.8673 per EA under NDC 00591245115. Its NADAC has been published 123 times since Apr 17, 2024.
FDA first approved this application on Mar 31, 2021. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Actavis Pharma, Inc.NDC
00591245115
Classification
Generic
Dosage Form
CAPSULE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ISOTRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA205063FDA Approved
3/31/2021
TE Code
AB2
On Market Since
4/29/2021
Pharmacological Classes
Price Statistics
The NADAC for ISOTRETINOIN 25 MG CAPSULE has been published 123 times since Apr 17, 2024, and over the history we have for it it has declined 36.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $10.8673 per EA |
|---|---|
| All-time high | $17.3949 (Jan 15, 2025) |
| All-time low | $10.4672 (May 20, 2026) |
| 52-week high | $10.9483 |
| 52-week low | $10.4672 |
| Median price | $11.2115 |
| Average price | $13.5506 |
| Largest weekly change | -13.2% (Apr 23, 2025) |
| Weeks tracked | 123 |
| Tracking since | Apr 17, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ISOTRETINOIN 25 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for ISOTRETINOIN 25 MG CAPSULE, manufactured by Actavis Pharma, Inc., is $10.8673 per EA (NDC 00591245115), effective Aug 19, 2026.
How has the price of ISOTRETINOIN 25 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for ISOTRETINOIN 25 MG CAPSULE has declined 36.0%. It has been tracked across 123 weekly CMS publications since Apr 17, 2024.
What are the highest and lowest recorded NADAC prices for ISOTRETINOIN 25 MG CAPSULE?
Since Apr 17, 2024, the NADAC for ISOTRETINOIN 25 MG CAPSULE has ranged from a low of $10.4672 (May 20, 2026) to a high of $17.3949 (Jan 15, 2025), with a median of $11.2115 per EA.
Are there cheaper alternatives to ISOTRETINOIN 25 MG CAPSULE?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ISOTRETINOIN 25 MG CAPSULE in a comparable dosage form, but none are currently priced below it.
Who manufactures ISOTRETINOIN 25 MG CAPSULE?
ISOTRETINOIN 25 MG CAPSULE (NDC 00591245115) is labeled by Actavis Pharma, Inc., and CMS classifies it as a generic product.