Product Information
TRETINOIN 0.025% GEL is a generic product labeled by Encube Ethicals, Inc., priced at $3.7790 per GM under NDC 21922005704. Its NADAC has been published 52 times since Aug 27, 2025.
FDA first approved this application on Mar 3, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922005704
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA217587FDA Approved
3/3/2025
TE Code
AB
On Market Since
3/6/2025
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.025% GEL has been published 52 times since Aug 27, 2025, and over the history we have for it it has risen 25.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.7790 per GM |
|---|---|
| All-time high | $3.7790 (Aug 19, 2026) |
| All-time low | $3.0067 (Aug 27, 2025) |
| 52-week high | $3.7790 |
| 52-week low | $3.0067 |
| Median price | $3.3796 |
| Average price | $3.4037 |
| Largest weekly change | +7.5% (Apr 22, 2026) |
| Weeks tracked | 52 |
| Tracking since | Aug 27, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 28% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of TRETINOIN 0.025% GEL?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.025% GEL, manufactured by Encube Ethicals, Inc., is $3.7790 per GM (NDC 21922005704), effective Aug 19, 2026.
How has the price of TRETINOIN 0.025% GEL changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.025% GEL has risen 25.7%. It has been tracked across 52 weekly CMS publications since Aug 27, 2025.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.025% GEL?
Since Aug 27, 2025, the NADAC for TRETINOIN 0.025% GEL has ranged from a low of $3.0067 (Aug 27, 2025) to a high of $3.7790 (Aug 19, 2026), with a median of $3.3796 per GM.
Are there cheaper alternatives to TRETINOIN 0.025% GEL?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.025% GEL, is $2.7073 per GM — about 28% below TRETINOIN 0.025% GEL.
Who manufactures TRETINOIN 0.025% GEL?
TRETINOIN 0.025% GEL (NDC 21922005704) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.