Product Information
TRETINOIN 0.025% GEL is a generic product labeled by Encube Ethicals, Inc., priced at $2.5002 per GM under NDC 21922005706. Its NADAC has been published 58 times since Aug 27, 2025.
FDA first approved this application on Mar 3, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922005706
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA217587FDA Approved
3/3/2025
TE Code
AB
On Market Since
3/6/2025
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.025% GEL has been published 58 times since Aug 27, 2025, and over the history we have for it it has risen 3.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.5002 per GM |
|---|---|
| All-time high | $2.7073 (Sep 16, 2026) |
| All-time low | $2.3908 (Sep 17, 2025) |
| 52-week high | $2.7073 |
| 52-week low | $2.3908 |
| Median price | $2.5158 |
| Average price | $2.5234 |
| Largest weekly change | -7.7% (Sep 23, 2026) |
| Weeks tracked | 58 |
| Tracking since | Aug 27, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of TRETINOIN 0.025% GEL?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.025% GEL, manufactured by Encube Ethicals, Inc., is $2.5002 per GM (NDC 21922005706), effective Sep 30, 2026.
How has the price of TRETINOIN 0.025% GEL changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.025% GEL has risen 3.2%. It has been tracked across 58 weekly CMS publications since Aug 27, 2025.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.025% GEL?
Since Aug 27, 2025, the NADAC for TRETINOIN 0.025% GEL has ranged from a low of $2.3908 (Sep 17, 2025) to a high of $2.7073 (Sep 16, 2026), with a median of $2.5158 per GM.
Are there cheaper alternatives to TRETINOIN 0.025% GEL?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as TRETINOIN 0.025% GEL in a comparable dosage form, but none are currently priced below it.
Who manufactures TRETINOIN 0.025% GEL?
TRETINOIN 0.025% GEL (NDC 21922005706) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.