Product Information
NALOXONE HCL 4 MG NASAL SPRAY is a generic product labeled by Amneal Pharmaceuticals NY LLC, priced at $17.1773 per EA under NDC 69238210407. Its NADAC has been published 117 times since Jul 10, 2024.
FDA first approved this application on Apr 23, 2024.
Strength
4 mg/.1mL
Manufacturer
Amneal Pharmaceuticals NY LLCNDC
69238210407
Classification
Generic
Dosage Form
SPRAY
Route
NASAL
Effective Date
9/23/2026
Active Ingredients
NALOXONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA217992FDA Approved
4/23/2024
On Market Since
4/24/2024
Pharmacological Classes
Price Statistics
The NADAC for NALOXONE HCL 4 MG NASAL SPRAY has been published 117 times since Jul 10, 2024, and over the history we have for it it has declined 55.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $17.1773 per EA |
|---|---|
| All-time high | $38.8039 (Jul 10, 2024) |
| All-time low | $15.2248 (May 20, 2026) |
| 52-week high | $22.8128 |
| 52-week low | $15.2248 |
| Median price | $23.1012 |
| Average price | $23.3452 |
| Largest weekly change | -32.4% (Nov 19, 2025) |
| Weeks tracked | 117 |
| Tracking since | Jul 10, 2024 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals NY LLC manufacturer profile
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Drug market
Naloxone Hydrochloride market comparison
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Therapeutic class
Opioid Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NALOXONE HCL 4 MG NASAL SPRAY?
The current National Average Drug Acquisition Cost (NADAC) for NALOXONE HCL 4 MG NASAL SPRAY, manufactured by Amneal Pharmaceuticals NY LLC, is $17.1773 per EA (NDC 69238210407), effective Sep 30, 2026.
How has the price of NALOXONE HCL 4 MG NASAL SPRAY changed over time?
Over the history we have for it, the NADAC for NALOXONE HCL 4 MG NASAL SPRAY has declined 55.7%. It has been tracked across 117 weekly CMS publications since Jul 10, 2024.
What are the highest and lowest recorded NADAC prices for NALOXONE HCL 4 MG NASAL SPRAY?
Since Jul 10, 2024, the NADAC for NALOXONE HCL 4 MG NASAL SPRAY has ranged from a low of $15.2248 (May 20, 2026) to a high of $38.8039 (Jul 10, 2024), with a median of $23.1012 per EA.
Are there cheaper alternatives to NALOXONE HCL 4 MG NASAL SPRAY?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as NALOXONE HCL 4 MG NASAL SPRAY in a comparable dosage form, but none are currently priced below it.
Who manufactures NALOXONE HCL 4 MG NASAL SPRAY?
NALOXONE HCL 4 MG NASAL SPRAY (NDC 69238210407) is labeled by Amneal Pharmaceuticals NY LLC, and CMS classifies it as a generic product.