Product Information
TRETINOIN 0.05% CREAM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $1.5482 per GM under NDC 00378808320. Its NADAC has been published 356 times since Sep 4, 2019.
Strength
.5 mg/g
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378808320
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Last Updated
6/17/2026
Active Ingredients
TRETINOINApproval Type
Authorized Generic (NDA)
FDA Application
NDA017522On Market Since
11/5/2018
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.05% CREAM has been published 356 times since Sep 4, 2019, and over the history we have for it it has declined 58.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.5482 per GM |
|---|---|
| All-time high | $3.7342 (Sep 11, 2019) |
| All-time low | $1.1766 (Nov 20, 2024) |
| 52-week high | $1.7086 |
| 52-week low | $1.5482 |
| Median price | $2.0046 |
| Average price | $2.3037 |
| Largest weekly change | +45.8% (Aug 21, 2024) |
| Weeks tracked | 356 |
| Tracking since | Sep 4, 2019 |
Generic Alternatives
The matcher finds 2 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 2 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 49% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.05% CREAM, manufactured by Mylan Pharmaceuticals Inc., is $1.5482 per GM (NDC 00378808320), effective Jun 24, 2026.
How has the price of TRETINOIN 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.05% CREAM has declined 58.5%. It has been tracked across 356 weekly CMS publications since Sep 4, 2019.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.05% CREAM?
Since Sep 4, 2019, the NADAC for TRETINOIN 0.05% CREAM has ranged from a low of $1.1766 (Nov 20, 2024) to a high of $3.7342 (Sep 11, 2019), with a median of $2.0046 per GM.
Are there cheaper alternatives to TRETINOIN 0.05% CREAM?
Yes. 2 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, RETIN-A 0.05% CREAM, is $0.7904 per GM — about 49% below TRETINOIN 0.05% CREAM.
Who manufactures TRETINOIN 0.05% CREAM?
TRETINOIN 0.05% CREAM (NDC 00378808320) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.
Related Drugs
Same classification