Product Information
TRETINOIN 0.05% CREAM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $1.6177 per GM under NDC 00378808320. Its NADAC has been published 370 times since Sep 4, 2019.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378808320
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Authorized Generic (NDA)
FDA Application
NDA017522FDA Approved
Before 1982
TE Code
AB1
On Market Since
11/5/2018
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.05% CREAM has been published 370 times since Sep 4, 2019, and over the history we have for it it has declined 56.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.6177 per GM |
|---|---|
| All-time high | $3.7342 (Sep 11, 2019) |
| All-time low | $1.1766 (Nov 20, 2024) |
| 52-week high | $1.7000 |
| 52-week low | $1.5482 |
| Median price | $2.0009 |
| Average price | $2.2758 |
| Largest weekly change | +45.8% (Aug 21, 2024) |
| Weeks tracked | 370 |
| Tracking since | Sep 4, 2019 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 51% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
Tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.05% CREAM, manufactured by Mylan Pharmaceuticals Inc., is $1.6177 per GM (NDC 00378808320), effective Sep 30, 2026.
How has the price of TRETINOIN 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.05% CREAM has declined 56.7%. It has been tracked across 370 weekly CMS publications since Sep 4, 2019.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.05% CREAM?
Since Sep 4, 2019, the NADAC for TRETINOIN 0.05% CREAM has ranged from a low of $1.1766 (Nov 20, 2024) to a high of $3.7342 (Sep 11, 2019), with a median of $2.0009 per GM.
Are there cheaper alternatives to TRETINOIN 0.05% CREAM?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, RETIN-A 0.05% CREAM, is $0.7904 per GM — about 51% below TRETINOIN 0.05% CREAM.
Who manufactures TRETINOIN 0.05% CREAM?
TRETINOIN 0.05% CREAM (NDC 00378808320) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.