Product Information
TRETINOIN 0.05% CREAM is a generic product labeled by Padagis US LLC, priced at $1.6177 per GM under NDC 00574220520. Its NADAC has been published 487 times since Jun 7, 2017.
FDA first approved this application on Dec 24, 1998. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Padagis US LLCNDC
00574220520
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA075265FDA Approved
12/24/1998
TE Code
AB1
On Market Since
4/26/2017
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.05% CREAM has been published 487 times since Jun 7, 2017, and over the history we have for it it has declined 58.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.6177 per GM |
|---|---|
| All-time high | $4.1995 (Jul 12, 2017) |
| All-time low | $1.1766 (Nov 20, 2024) |
| 52-week high | $1.7000 |
| 52-week low | $1.5482 |
| Median price | $2.3906 |
| Average price | $2.6196 |
| Largest weekly change | +45.8% (Aug 21, 2024) |
| Weeks tracked | 487 |
| Tracking since | Jun 7, 2017 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 35% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis US LLC manufacturer profile
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Drug market
tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.05% CREAM, manufactured by Padagis US LLC, is $1.6177 per GM (NDC 00574220520), effective Sep 30, 2026.
How has the price of TRETINOIN 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.05% CREAM has declined 58.0%. It has been tracked across 487 weekly CMS publications since Jun 7, 2017.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.05% CREAM?
Since Jun 7, 2017, the NADAC for TRETINOIN 0.05% CREAM has ranged from a low of $1.1766 (Nov 20, 2024) to a high of $4.1995 (Jul 12, 2017), with a median of $2.3906 per GM.
Are there cheaper alternatives to TRETINOIN 0.05% CREAM?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.05% CREAM, is $1.0505 per GM — about 35% below TRETINOIN 0.05% CREAM.
Who manufactures TRETINOIN 0.05% CREAM?
TRETINOIN 0.05% CREAM (NDC 00574220520) is labeled by Padagis US LLC, and CMS classifies it as a generic product.