Product Information
TRETINOIN 0.05% CREAM is a generic product labeled by Padagis US LLC, priced at $1.5688 per GM under NDC 00574220520. Its NADAC has been published 481 times since Jun 7, 2017.
FDA first approved this application on Dec 24, 1998. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/g
Manufacturer
Padagis US LLCNDC
00574220520
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA075265FDA Approved
12/24/1998
TE Code
AB1
On Market Since
4/26/2017
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.05% CREAM has been published 481 times since Jun 7, 2017, and over the history we have for it it has declined 59.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.5688 per GM |
|---|---|
| All-time high | $4.1995 (Jul 12, 2017) |
| All-time low | $1.1766 (Nov 20, 2024) |
| 52-week high | $1.7000 |
| 52-week low | $1.5482 |
| Median price | $2.4068 |
| Average price | $2.6325 |
| Largest weekly change | +45.8% (Aug 21, 2024) |
| Weeks tracked | 481 |
| Tracking since | Jun 7, 2017 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 41% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of TRETINOIN 0.05% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.05% CREAM, manufactured by Padagis US LLC, is $1.5688 per GM (NDC 00574220520), effective Aug 19, 2026.
How has the price of TRETINOIN 0.05% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.05% CREAM has declined 59.2%. It has been tracked across 481 weekly CMS publications since Jun 7, 2017.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.05% CREAM?
Since Jun 7, 2017, the NADAC for TRETINOIN 0.05% CREAM has ranged from a low of $1.1766 (Nov 20, 2024) to a high of $4.1995 (Jul 12, 2017), with a median of $2.4068 per GM.
Are there cheaper alternatives to TRETINOIN 0.05% CREAM?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.05% CREAM, is $0.9284 per GM — about 41% below TRETINOIN 0.05% CREAM.
Who manufactures TRETINOIN 0.05% CREAM?
TRETINOIN 0.05% CREAM (NDC 00574220520) is labeled by Padagis US LLC, and CMS classifies it as a generic product.