Product Information
TRETINOIN 0.025% CREAM is a generic product labeled by Padagis US LLC, priced at $0.5535 per GM under NDC 00574222520. Its NADAC has been published 463 times since Oct 11, 2017.
FDA first approved this application on Dec 24, 1998. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/g
Manufacturer
Padagis US LLCNDC
00574222520
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA075264FDA Approved
12/24/1998
TE Code
AB
On Market Since
6/15/2017
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.025% CREAM has been published 463 times since Oct 11, 2017, and over the history we have for it it has declined 81.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5535 per GM |
|---|---|
| All-time high | $3.3664 (Sep 12, 2018) |
| All-time low | $0.5535 (Aug 19, 2026) |
| 52-week high | $1.0981 |
| 52-week low | $0.5535 |
| Median price | $2.0474 |
| Average price | $1.8274 |
| Largest weekly change | +51.5% (Oct 21, 2020) |
| Weeks tracked | 463 |
| Tracking since | Oct 11, 2017 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 15% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of TRETINOIN 0.025% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.025% CREAM, manufactured by Padagis US LLC, is $0.5535 per GM (NDC 00574222520), effective Aug 19, 2026.
How has the price of TRETINOIN 0.025% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.025% CREAM has declined 81.8%. It has been tracked across 463 weekly CMS publications since Oct 11, 2017.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.025% CREAM?
Since Oct 11, 2017, the NADAC for TRETINOIN 0.025% CREAM has ranged from a low of $0.5535 (Aug 19, 2026) to a high of $3.3664 (Sep 12, 2018), with a median of $2.0474 per GM.
Are there cheaper alternatives to TRETINOIN 0.025% CREAM?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.025% CREAM, is $0.4684 per GM — about 15% below TRETINOIN 0.025% CREAM.
Who manufactures TRETINOIN 0.025% CREAM?
TRETINOIN 0.025% CREAM (NDC 00574222520) is labeled by Padagis US LLC, and CMS classifies it as a generic product.