Product Information
TRETINOIN 0.01% GEL is a generic product labeled by Encube Ethicals, Inc., priced at $2.7399 per GM under NDC 21922005604. Its NADAC has been published 58 times since Aug 27, 2025.
FDA first approved this application on Mar 3, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922005604
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA217588FDA Approved
3/3/2025
TE Code
AB
On Market Since
3/6/2025
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.01% GEL has been published 58 times since Aug 27, 2025, and over the history we have for it it has declined 21.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.7399 per GM |
|---|---|
| All-time high | $3.5061 (Feb 11, 2026) |
| All-time low | $2.7399 (Sep 23, 2026) |
| 52-week high | $3.5061 |
| 52-week low | $2.7399 |
| Median price | $3.3961 |
| Average price | $3.3564 |
| Largest weekly change | -12.0% (Sep 23, 2026) |
| Weeks tracked | 58 |
| Tracking since | Aug 27, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 65% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.01% GEL?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.01% GEL, manufactured by Encube Ethicals, Inc., is $2.7399 per GM (NDC 21922005604), effective Sep 30, 2026.
How has the price of TRETINOIN 0.01% GEL changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.01% GEL has declined 21.0%. It has been tracked across 58 weekly CMS publications since Aug 27, 2025.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.01% GEL?
Since Aug 27, 2025, the NADAC for TRETINOIN 0.01% GEL has ranged from a low of $2.7399 (Sep 23, 2026) to a high of $3.5061 (Feb 11, 2026), with a median of $3.3961 per GM.
Are there cheaper alternatives to TRETINOIN 0.01% GEL?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, RETIN-A 0.01% GEL, is $0.9570 per GM — about 65% below TRETINOIN 0.01% GEL.
Who manufactures TRETINOIN 0.01% GEL?
TRETINOIN 0.01% GEL (NDC 21922005604) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.