Product Information
TRETINOIN 0.01% GEL is a generic product labeled by Encube Ethicals, Inc., priced at $2.2768 per GM under NDC 21922005606. Its NADAC has been published 44 times since Aug 27, 2025.
Strength
.1 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922005606
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Last Updated
6/17/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA217588On Market Since
3/6/2025
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.01% GEL has been published 44 times since Aug 27, 2025, and over the history we have for it it has declined 8.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.2768 per GM |
|---|---|
| All-time high | $2.4992 (Sep 10, 2025) |
| All-time low | $2.1587 (Feb 18, 2026) |
| 52-week high | $2.4992 |
| 52-week low | $2.1587 |
| Median price | $2.3139 |
| Average price | $2.3094 |
| Largest weekly change | -7.4% (Sep 17, 2025) |
| Weeks tracked | 44 |
| Tracking since | Aug 27, 2025 |
Generic Alternatives
The matcher finds 3 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 3 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 58% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.01% GEL?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.01% GEL, manufactured by Encube Ethicals, Inc., is $2.2768 per GM (NDC 21922005606), effective Jun 24, 2026.
How has the price of TRETINOIN 0.01% GEL changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.01% GEL has declined 8.9%. It has been tracked across 44 weekly CMS publications since Aug 27, 2025.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.01% GEL?
Since Aug 27, 2025, the NADAC for TRETINOIN 0.01% GEL has ranged from a low of $2.1587 (Feb 18, 2026) to a high of $2.4992 (Sep 10, 2025), with a median of $2.3139 per GM.
Are there cheaper alternatives to TRETINOIN 0.01% GEL?
Yes. 3 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, RETIN-A 0.01% GEL, is $0.9570 per GM — about 58% below TRETINOIN 0.01% GEL.
Who manufactures TRETINOIN 0.01% GEL?
TRETINOIN 0.01% GEL (NDC 21922005606) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.
Related Drugs
Same classification