Product Information
GNP NALOXONE HCL 4 MG NASAL SP is a generic product labeled by AmerisourceBergen, priced at $16.9224 per EA under NDC 46122081271. Its NADAC has been published 61 times since Jun 25, 2025.
FDA first approved this application on Jun 21, 2022.
Strength
4 mg/.1mL
Manufacturer
AmerisourceBergenNDC
46122081271
Classification
Generic
Dosage Form
SPRAY
Route
NASAL
Effective Date
8/19/2026
Active Ingredients
NALOXONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA211951FDA Approved
6/21/2022
On Market Since
3/12/2025
Pharmacological Classes
Price Statistics
The NADAC for GNP NALOXONE HCL 4 MG NASAL SP has been published 61 times since Jun 25, 2025, and over the history we have for it it has declined 35.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $16.9224 per EA |
|---|---|
| All-time high | $26.2968 (Jul 16, 2025) |
| All-time low | $15.2248 (May 20, 2026) |
| 52-week high | $23.1012 |
| 52-week low | $15.2248 |
| Median price | $15.4599 |
| Average price | $18.4527 |
| Largest weekly change | -32.4% (Nov 19, 2025) |
| Weeks tracked | 61 |
| Tracking since | Jun 25, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of GNP NALOXONE HCL 4 MG NASAL SP?
The current National Average Drug Acquisition Cost (NADAC) for GNP NALOXONE HCL 4 MG NASAL SP, manufactured by AmerisourceBergen, is $16.9224 per EA (NDC 46122081271), effective Aug 19, 2026.
How has the price of GNP NALOXONE HCL 4 MG NASAL SP changed over time?
Over the history we have for it, the NADAC for GNP NALOXONE HCL 4 MG NASAL SP has declined 35.6%. It has been tracked across 61 weekly CMS publications since Jun 25, 2025.
What are the highest and lowest recorded NADAC prices for GNP NALOXONE HCL 4 MG NASAL SP?
Since Jun 25, 2025, the NADAC for GNP NALOXONE HCL 4 MG NASAL SP has ranged from a low of $15.2248 (May 20, 2026) to a high of $26.2968 (Jul 16, 2025), with a median of $15.4599 per EA.
Are there cheaper alternatives to GNP NALOXONE HCL 4 MG NASAL SP?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as GNP NALOXONE HCL 4 MG NASAL SP in a comparable dosage form, but none are currently priced below it.
Who manufactures GNP NALOXONE HCL 4 MG NASAL SP?
GNP NALOXONE HCL 4 MG NASAL SP (NDC 46122081271) is labeled by AmerisourceBergen, and CMS classifies it as a generic product.