This NDC is on FDA's drug shortage list (posted Mar 13, 2023)
Product Information
METHOTREXATE 50 MG/2 ML VIAL is a generic product labeled by Hospira Inc., priced at $3.1283 per ML under NDC 61703035010. Its NADAC has been published 324 times since Jun 10, 2020.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AP.
Strength
25 mg/mL
Manufacturer
Hospira Inc.NDC
61703035010
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Effective Date
8/19/2026
Active Ingredients
METHOTREXATE SODIUMApproval Type
New Drug (NDA)
FDA Application
NDA011719FDA Approved
Before 1982
TE Code
AP
On Market Since
9/25/2014
Pharmacological Classes
Price Statistics
The NADAC for METHOTREXATE 50 MG/2 ML VIAL has been published 324 times since Jun 10, 2020, and over the history we have for it it has declined 6.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.1283 per ML |
|---|---|
| All-time high | $3.4029 (Feb 16, 2022) |
| All-time low | $2.6573 (Jul 17, 2024) |
| 52-week high | $3.3602 |
| 52-week low | $3.0533 |
| Median price | $3.1788 |
| Average price | $3.1650 |
| Largest weekly change | -20.7% (Jul 17, 2024) |
| Weeks tracked | 324 |
| Tracking since | Jun 10, 2020 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 79% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHOTREXATE 50 MG/2 ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for METHOTREXATE 50 MG/2 ML VIAL, manufactured by Hospira Inc., is $3.1283 per ML (NDC 61703035010), effective Aug 19, 2026.
How has the price of METHOTREXATE 50 MG/2 ML VIAL changed over time?
Over the history we have for it, the NADAC for METHOTREXATE 50 MG/2 ML VIAL has declined 6.0%. It has been tracked across 324 weekly CMS publications since Jun 10, 2020.
What are the highest and lowest recorded NADAC prices for METHOTREXATE 50 MG/2 ML VIAL?
Since Jun 10, 2020, the NADAC for METHOTREXATE 50 MG/2 ML VIAL has ranged from a low of $2.6573 (Jul 17, 2024) to a high of $3.4029 (Feb 16, 2022), with a median of $3.1788 per ML.
Are there cheaper alternatives to METHOTREXATE 50 MG/2 ML VIAL?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, METHOTREXATE 1 GRAM/40 ML VIAL, is $0.6450 per ML — about 79% below METHOTREXATE 50 MG/2 ML VIAL.
Who manufactures METHOTREXATE 50 MG/2 ML VIAL?
METHOTREXATE 50 MG/2 ML VIAL (NDC 61703035010) is labeled by Hospira Inc., and CMS classifies it as a generic product.
Is METHOTREXATE 50 MG/2 ML VIAL in shortage?
Yes — NDC 61703035010 is currently listed in FDA's drug shortage database (posted Mar 13, 2023).