This NDC is on FDA's drug shortage list (posted Mar 13, 2023)
Product Information
METHOTREXATE 50 MG/2 ML VIAL is a generic product labeled by Hospira Inc., priced at $3.1283 per ML under NDC 61703035038. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AP.
Strength
25 mg/mL
Manufacturer
Hospira Inc.NDC
61703035038
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Effective Date
8/19/2026
Active Ingredients
METHOTREXATE SODIUMApproval Type
New Drug (NDA)
FDA Application
NDA011719FDA Approved
Before 1982
TE Code
AP
On Market Since
9/25/2014
Pharmacological Classes
Price Statistics
The NADAC for METHOTREXATE 50 MG/2 ML VIAL has been published 665 times since Nov 28, 2013, and over the history we have for it it has risen 26.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.1283 per ML |
|---|---|
| All-time high | $3.5278 (Jul 15, 2015) |
| All-time low | $2.4714 (Nov 28, 2013) |
| 52-week high | $3.3602 |
| 52-week low | $3.0533 |
| Median price | $3.2008 |
| Average price | $3.1760 |
| Largest weekly change | -20.7% (Jul 17, 2024) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 79% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHOTREXATE 50 MG/2 ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for METHOTREXATE 50 MG/2 ML VIAL, manufactured by Hospira Inc., is $3.1283 per ML (NDC 61703035038), effective Aug 19, 2026.
How has the price of METHOTREXATE 50 MG/2 ML VIAL changed over time?
Over the history we have for it, the NADAC for METHOTREXATE 50 MG/2 ML VIAL has risen 26.6%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for METHOTREXATE 50 MG/2 ML VIAL?
Since Nov 28, 2013, the NADAC for METHOTREXATE 50 MG/2 ML VIAL has ranged from a low of $2.4714 (Nov 28, 2013) to a high of $3.5278 (Jul 15, 2015), with a median of $3.2008 per ML.
Are there cheaper alternatives to METHOTREXATE 50 MG/2 ML VIAL?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, METHOTREXATE 1 GRAM/40 ML VIAL, is $0.6450 per ML — about 79% below METHOTREXATE 50 MG/2 ML VIAL.
Who manufactures METHOTREXATE 50 MG/2 ML VIAL?
METHOTREXATE 50 MG/2 ML VIAL (NDC 61703035038) is labeled by Hospira Inc., and CMS classifies it as a generic product.
Is METHOTREXATE 50 MG/2 ML VIAL in shortage?
Yes — NDC 61703035038 is currently listed in FDA's drug shortage database (posted Mar 13, 2023).