Alprazolam
81 NDCs across 10 manufacturers|68 Generic,13 Brand
Alprazolam is used to treat agoraphobia, depressive disorder and panic disorder, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Oct 19, 1993. FDA's Orange Book lists 48 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $77 million on Alprazolam across 11.7 million claims for 2.3 million beneficiaries.
Alprazolam is available as 81 NDCs from 10 manufacturers (68 generic, 13 brand), with NADAC prices from $0.02 to $15.91 per EA — the most expensive product costs about 709× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
81
68G / 13B
Manufacturers
10
competing in market
Price Spread
$0.02 – $15.91
per EA, 80 of 81 NDCs
7d Activity
avg +0.1% WoW · of 81 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Actavis Pharma, Inc. manufacturer profile
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Lead class
Benzodiazepine class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
10 manufacturers producing ALPRAZOLAM(2 pricing outliers)
Frequently Asked Questions
What is Alprazolam used to treat?
Alprazolam is used to treat agoraphobia, depressive disorder and panic disorder, per the National Library of Medicine's MED-RT classification.
When did Alprazolam become available as a generic?
FDA approved the first generic Alprazolam (ANDA) on Oct 19, 1993. The Orange Book currently lists 48 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Alprazolam?
In 2024, Medicare Part D spent $77 million on Alprazolam across 11.7 million claims for 2.3 million beneficiaries.
How many Alprazolam products are on the market?
The Alprazolam drug market contains 81 NDCs from 10 manufacturers — 68 generic and 13 brand products.
What is the price range for Alprazolam?
NADAC reference prices for Alprazolam range from $0.0225 to $15.9099 per EA — the most expensive product costs about 709× the cheapest. 1 additional product is priced per a different unit (e.g. liquids per ML) and isn't directly comparable.
Is generic Alprazolam cheaper than brand?
The average generic NADAC for Alprazolam is $0.2013 per EA, versus $8.5033 for brand-labeled products — brand versions average about 42× the generic price.
Which manufacturers make Alprazolam?
10 manufacturers list Alprazolam in NADAC. Ranked by number of NDCs, the largest are Actavis Pharma, Inc. (17), Aurobindo Pharma Limited (15), Mylan Pharmaceuticals Inc. (15), Sandoz Inc. (11), Pharmacia & Upjohn Company LLC (7).
How has the price of Alprazolam changed recently?
Over the past 7 days, 42 Alprazolam NDCs rose and 26 fell, with a market-wide average change of +0.1%.