Lubiprostone
20 NDCs across 11 manufacturers|17 Generic,3 Brand
Lubiprostone is used to treat constipation and irritable bowel syndrome, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on Jan 31, 2006, and the first generic was approved Nov 30, 2021. FDA's Orange Book lists 12 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $59 million on Lubiprostone across 447,000 claims for 123,000 beneficiaries.
Lubiprostone is available as 20 NDCs from 11 manufacturers (17 generic, 3 brand), with NADAC prices from $0.57 to $6.47 per EA — the most expensive product costs about 11× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
20
17G / 3B
Manufacturers
11
competing in market
Price Spread
$0.57 – $6.47
per EA
7d Activity
avg +3.6% WoW · of 20 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
SpecGx LLC manufacturer profile
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Lead class
Chloride Channel Activator class view
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Trend hub
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Guide
How to interpret NADAC
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Manufacturer Breakdown
11 manufacturers producing LUBIPROSTONE(2 pricing outliers)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
AMITIZA 8 MCG CAPSULE | $6.4677 per EA | — |
AMITIZA 24 MCG CAPSULE | $6.4489 per EA | — |
AMITIZA 24 MCG CAPSULE | $5.9498 per EA | — |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 24 MCG CAPSULE | $0.6507 per EA | +4.30% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
LUBIPROSTONE 8 MCG CAPSULE | $0.5652 per EA | +2.89% |
Frequently Asked Questions
What is Lubiprostone used to treat?
Lubiprostone is used to treat constipation and irritable bowel syndrome, per the National Library of Medicine's MED-RT classification.
When did Lubiprostone become available as a generic?
FDA approved the first generic Lubiprostone (ANDA) on Nov 30, 2021. The Orange Book currently lists 12 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Lubiprostone?
In 2024, Medicare Part D spent $59 million on Lubiprostone across 447,000 claims for 123,000 beneficiaries.
How many Lubiprostone products are on the market?
The Lubiprostone drug market contains 20 NDCs from 11 manufacturers — 17 generic and 3 brand products.
What is the price range for Lubiprostone?
NADAC reference prices for Lubiprostone range from $0.5652 to $6.4677 per EA — the most expensive product costs about 11× the cheapest.
Is generic Lubiprostone cheaper than brand?
The average generic NADAC for Lubiprostone is $0.6105 per EA, versus $6.2888 for brand-labeled products — brand versions average about 10× the generic price.
Which manufacturers make Lubiprostone?
11 manufacturers list Lubiprostone in NADAC. Ranked by number of NDCs, the largest are SpecGx LLC (2), Camber Pharmaceuticals Inc. (2), Dr. Reddy's Laboratories Inc. (2), Sun Pharmaceutical Industries Inc. (2), Par Health USA, LLC (2).
How has the price of Lubiprostone changed recently?
Over the past 7 days, 17 Lubiprostone NDCs rose and 0 fell, with a market-wide average change of +3.6%.