Product Information
ISOTRETINOIN 40 MG CAPSULE is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $6.7472 per EA under NDC 00245057501. Its NADAC has been published 237 times since Feb 9, 2022.
FDA first approved this application on Apr 12, 2021. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/1
Manufacturer
Upsher-Smith Laboratories LLCNDC
00245057501
Classification
Generic
Dosage Form
CAPSULE, LIQUID FILLED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ISOTRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA213571FDA Approved
4/12/2021
TE Code
AB2
On Market Since
4/12/2021
Pharmacological Classes
Price Statistics
The NADAC for ISOTRETINOIN 40 MG CAPSULE has been published 237 times since Feb 9, 2022, and over the history we have for it it has declined 74.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $6.7472 per EA |
|---|---|
| All-time high | $26.7665 (Jun 15, 2022) |
| All-time low | $5.0999 (May 20, 2026) |
| 52-week high | $15.9249 |
| 52-week low | $5.0999 |
| Median price | $15.1870 |
| Average price | $15.6976 |
| Largest weekly change | -43.3% (Jun 22, 2022) |
| Weeks tracked | 237 |
| Tracking since | Feb 9, 2022 |
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 68% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ISOTRETINOIN 40 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for ISOTRETINOIN 40 MG CAPSULE, manufactured by Upsher-Smith Laboratories LLC, is $6.7472 per EA (NDC 00245057501), effective Aug 19, 2026.
How has the price of ISOTRETINOIN 40 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for ISOTRETINOIN 40 MG CAPSULE has declined 74.8%. It has been tracked across 237 weekly CMS publications since Feb 9, 2022.
What are the highest and lowest recorded NADAC prices for ISOTRETINOIN 40 MG CAPSULE?
Since Feb 9, 2022, the NADAC for ISOTRETINOIN 40 MG CAPSULE has ranged from a low of $5.0999 (May 20, 2026) to a high of $26.7665 (Jun 15, 2022), with a median of $15.1870 per EA.
Are there cheaper alternatives to ISOTRETINOIN 40 MG CAPSULE?
Yes. 7 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ISOTRETINOIN 40 MG CAPSULE, is $2.1849 per EA — about 68% below ISOTRETINOIN 40 MG CAPSULE.
Who manufactures ISOTRETINOIN 40 MG CAPSULE?
ISOTRETINOIN 40 MG CAPSULE (NDC 00245057501) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.