Product Information
ISOTRETINOIN 40 MG CAPSULE is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $5.3067 per EA under NDC 00245057501. Its NADAC has been published 229 times since Feb 9, 2022.
Strength
40 mg/1
Manufacturer
Upsher-Smith Laboratories LLCNDC
00245057501
Classification
Generic
Dosage Form
CAPSULE, LIQUID FILLED
Route
ORAL
Last Updated
6/17/2026
Active Ingredients
ISOTRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA213571On Market Since
4/12/2021
Pharmacological Classes
Price Statistics
The NADAC for ISOTRETINOIN 40 MG CAPSULE has been published 229 times since Feb 9, 2022, and over the history we have for it it has declined 80.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $5.3067 per EA |
|---|---|
| All-time high | $26.7665 (Jun 15, 2022) |
| All-time low | $5.0999 (May 20, 2026) |
| 52-week high | $15.9249 |
| 52-week low | $5.0999 |
| Median price | $15.1870 |
| Average price | $16.0472 |
| Largest weekly change | -43.3% (Jun 22, 2022) |
| Weeks tracked | 229 |
| Tracking since | Feb 9, 2022 |
Generic Alternatives
The matcher finds 7 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 7 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 59% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of ISOTRETINOIN 40 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for ISOTRETINOIN 40 MG CAPSULE, manufactured by Upsher-Smith Laboratories LLC, is $5.3067 per EA (NDC 00245057501), effective Jun 24, 2026.
How has the price of ISOTRETINOIN 40 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for ISOTRETINOIN 40 MG CAPSULE has declined 80.2%. It has been tracked across 229 weekly CMS publications since Feb 9, 2022.
What are the highest and lowest recorded NADAC prices for ISOTRETINOIN 40 MG CAPSULE?
Since Feb 9, 2022, the NADAC for ISOTRETINOIN 40 MG CAPSULE has ranged from a low of $5.0999 (May 20, 2026) to a high of $26.7665 (Jun 15, 2022), with a median of $15.1870 per EA.
Are there cheaper alternatives to ISOTRETINOIN 40 MG CAPSULE?
Yes. 7 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, ISOTRETINOIN 40 MG CAPSULE, is $2.1672 per EA — about 59% below ISOTRETINOIN 40 MG CAPSULE.
Who manufactures ISOTRETINOIN 40 MG CAPSULE?
ISOTRETINOIN 40 MG CAPSULE (NDC 00245057501) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.
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Same classification