Product Information
TRETINOIN 0.1% CREAM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $0.9575 per GM under NDC 00378808420. Its NADAC has been published 364 times since Sep 4, 2019.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378808420
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
TRETINOINApproval Type
Authorized Generic (NDA)
FDA Application
NDA017340FDA Approved
Before 1982
TE Code
AB
On Market Since
2/27/2019
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.1% CREAM has been published 364 times since Sep 4, 2019, and over the history we have for it it has declined 79.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9575 per GM |
|---|---|
| All-time high | $4.8464 (Mar 11, 2020) |
| All-time low | $0.9421 (Jul 22, 2026) |
| 52-week high | $1.4053 |
| 52-week low | $0.9421 |
| Median price | $2.4341 |
| Average price | $2.6418 |
| Largest weekly change | -36.0% (Nov 20, 2024) |
| Weeks tracked | 364 |
| Tracking since | Sep 4, 2019 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 20% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of TRETINOIN 0.1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.1% CREAM, manufactured by Mylan Pharmaceuticals Inc., is $0.9575 per GM (NDC 00378808420), effective Aug 19, 2026.
How has the price of TRETINOIN 0.1% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.1% CREAM has declined 79.8%. It has been tracked across 364 weekly CMS publications since Sep 4, 2019.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.1% CREAM?
Since Sep 4, 2019, the NADAC for TRETINOIN 0.1% CREAM has ranged from a low of $0.9421 (Jul 22, 2026) to a high of $4.8464 (Mar 11, 2020), with a median of $2.4341 per GM.
Are there cheaper alternatives to TRETINOIN 0.1% CREAM?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.1% CREAM, is $0.7625 per GM — about 20% below TRETINOIN 0.1% CREAM.
Who manufactures TRETINOIN 0.1% CREAM?
TRETINOIN 0.1% CREAM (NDC 00378808420) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.