Product Information
NALOXONE 0.4 MG/ML VIAL is a generic product labeled by Mylan Institutional LLC, priced at $3.8243 per ML under NDC 67457029202. Its NADAC has been published 378 times since Dec 23, 2015.
FDA first approved this application on Mar 6, 2014. Its Orange Book therapeutic-equivalence code is AP.
Strength
.4 mg/mL
Manufacturer
Mylan Institutional LLCNDC
67457029202
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Effective Date
9/23/2026
Active Ingredients
NALOXONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA204997FDA Approved
3/6/2014
TE Code
AP
On Market Since
3/6/2014
Pharmacological Classes
Price Statistics
The NADAC for NALOXONE 0.4 MG/ML VIAL has been published 378 times since Dec 23, 2015, and over the history we have for it it has declined 74.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $3.8243 per ML |
|---|---|
| All-time high | $15.7839 (Aug 16, 2017) |
| All-time low | $3.8172 (Dec 17, 2025) |
| 52-week high | $4.8188 |
| 52-week low | $3.8172 |
| Median price | $11.2094 |
| Average price | $9.6947 |
| Largest weekly change | -42.1% (Jul 20, 2022) |
| Weeks tracked | 378 |
| Tracking since | Dec 23, 2015 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mylan Institutional LLC manufacturer profile
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Drug market
naloxone hydrochloride market comparison
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Therapeutic class
Opioid Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NALOXONE 0.4 MG/ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for NALOXONE 0.4 MG/ML VIAL, manufactured by Mylan Institutional LLC, is $3.8243 per ML (NDC 67457029202), effective Sep 30, 2026.
How has the price of NALOXONE 0.4 MG/ML VIAL changed over time?
Over the history we have for it, the NADAC for NALOXONE 0.4 MG/ML VIAL has declined 74.6%. It has been tracked across 378 weekly CMS publications since Dec 23, 2015.
What are the highest and lowest recorded NADAC prices for NALOXONE 0.4 MG/ML VIAL?
Since Dec 23, 2015, the NADAC for NALOXONE 0.4 MG/ML VIAL has ranged from a low of $3.8172 (Dec 17, 2025) to a high of $15.7839 (Aug 16, 2017), with a median of $11.2094 per ML.
Are there cheaper alternatives to NALOXONE 0.4 MG/ML VIAL?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as NALOXONE 0.4 MG/ML VIAL in a comparable dosage form, but none are currently priced below it.
Who manufactures NALOXONE 0.4 MG/ML VIAL?
NALOXONE 0.4 MG/ML VIAL (NDC 67457029202) is labeled by Mylan Institutional LLC, and CMS classifies it as a generic product.