Product Information
NALOXONE 0.4 MG/ML VIAL is a generic product labeled by Mylan Institutional LLC, priced at $4.0147 per ML under NDC 67457064502. Its NADAC has been published 218 times since May 26, 2021.
FDA first approved this application on Mar 6, 2014. Its Orange Book therapeutic-equivalence code is AP.
Strength
.4 mg/mL
Manufacturer
Mylan Institutional LLCNDC
67457064502
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Effective Date
8/19/2026
Active Ingredients
NALOXONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA204997FDA Approved
3/6/2014
TE Code
AP
On Market Since
1/24/2020
Pharmacological Classes
Price Statistics
The NADAC for NALOXONE 0.4 MG/ML VIAL has been published 218 times since May 26, 2021, and over the history we have for it it has declined 64.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $4.0147 per ML |
|---|---|
| All-time high | $11.2094 (Mar 16, 2022) |
| All-time low | $3.8172 (Dec 17, 2025) |
| 52-week high | $4.8188 |
| 52-week low | $3.8172 |
| Median price | $6.4882 |
| Average price | $6.8328 |
| Largest weekly change | -42.1% (Jul 20, 2022) |
| Weeks tracked | 218 |
| Tracking since | May 26, 2021 |
1W
N/A
1M
N/A
3M
-9.0%
6M
-1.8%
1Y
-16.7%
3Y
-38.1%
5Y
-64.2%
All
-64.2%
Last surveyed Aug 19, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 5% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Mylan Institutional LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
naloxone hydrochloride market comparison
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Therapeutic class
Opioid Antagonist class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NALOXONE 0.4 MG/ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for NALOXONE 0.4 MG/ML VIAL, manufactured by Mylan Institutional LLC, is $4.0147 per ML (NDC 67457064502), effective Aug 19, 2026.
How has the price of NALOXONE 0.4 MG/ML VIAL changed over time?
Over the history we have for it, the NADAC for NALOXONE 0.4 MG/ML VIAL has declined 64.2%. It has been tracked across 218 weekly CMS publications since May 26, 2021.
What are the highest and lowest recorded NADAC prices for NALOXONE 0.4 MG/ML VIAL?
Since May 26, 2021, the NADAC for NALOXONE 0.4 MG/ML VIAL has ranged from a low of $3.8172 (Dec 17, 2025) to a high of $11.2094 (Mar 16, 2022), with a median of $6.4882 per ML.
Are there cheaper alternatives to NALOXONE 0.4 MG/ML VIAL?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, NALOXONE 0.4 MG/ML VIAL, is $3.8243 per ML — about 5% below NALOXONE 0.4 MG/ML VIAL.
Who manufactures NALOXONE 0.4 MG/ML VIAL?
NALOXONE 0.4 MG/ML VIAL (NDC 67457064502) is labeled by Mylan Institutional LLC, and CMS classifies it as a generic product.