Product Information
ISOTRETINOIN 40 MG CAPSULE is a generic product labeled by Mayne Pharma, priced at $6.6653 per EA under NDC 68308057530. Its NADAC has been published 257 times since Nov 3, 2021.
FDA first approved this application on Apr 12, 2021. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
40 mg/1
Manufacturer
Mayne PharmaNDC
68308057530
Classification
Generic
Dosage Form
CAPSULE, LIQUID FILLED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ISOTRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA213571FDA Approved
4/12/2021
TE Code
AB2
On Market Since
9/3/2021
Pharmacological Classes
Price Statistics
The NADAC for ISOTRETINOIN 40 MG CAPSULE has been published 257 times since Nov 3, 2021, and over the history we have for it it has declined 75.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $6.6653 per EA |
|---|---|
| All-time high | $26.7665 (Jun 15, 2022) |
| All-time low | $5.0999 (May 20, 2026) |
| 52-week high | $15.9249 |
| 52-week low | $5.0999 |
| Median price | $15.1870 |
| Average price | $16.0910 |
| Largest weekly change | -43.3% (Jun 22, 2022) |
| Weeks tracked | 257 |
| Tracking since | Nov 3, 2021 |
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 67% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Mayne Pharma manufacturer profile
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Drug market
Isotretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ISOTRETINOIN 40 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for ISOTRETINOIN 40 MG CAPSULE, manufactured by Mayne Pharma, is $6.6653 per EA (NDC 68308057530), effective Sep 30, 2026.
How has the price of ISOTRETINOIN 40 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for ISOTRETINOIN 40 MG CAPSULE has declined 75.1%. It has been tracked across 257 weekly CMS publications since Nov 3, 2021.
What are the highest and lowest recorded NADAC prices for ISOTRETINOIN 40 MG CAPSULE?
Since Nov 3, 2021, the NADAC for ISOTRETINOIN 40 MG CAPSULE has ranged from a low of $5.0999 (May 20, 2026) to a high of $26.7665 (Jun 15, 2022), with a median of $15.1870 per EA.
Are there cheaper alternatives to ISOTRETINOIN 40 MG CAPSULE?
Yes. 7 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ISOTRETINOIN 40 MG CAPSULE, is $2.2078 per EA — about 67% below ISOTRETINOIN 40 MG CAPSULE.
Who manufactures ISOTRETINOIN 40 MG CAPSULE?
ISOTRETINOIN 40 MG CAPSULE (NDC 68308057530) is labeled by Mayne Pharma, and CMS classifies it as a generic product.