Product Information
PROMETHEGAN 12.5 MG SUPPOS is a generic product labeled by Cosette Pharmaceuticals, Inc., priced at $1.8586 per EA under NDC 00713053612. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application on Feb 5, 2002. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the promethazine hydrochloride market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
12.5 mg/1
Manufacturer
Cosette Pharmaceuticals, Inc.NDC
00713053612
Classification
Generic
Dosage Form
SUPPOSITORY
Route
RECTAL
Effective Date
8/19/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040428FDA Approved
2/5/2002
TE Code
AB
On Market Since
2/28/2004
Pharmacological Classes
Price Statistics
The NADAC for PROMETHEGAN 12.5 MG SUPPOS has been published 665 times since Nov 28, 2013, and over the history we have for it it has declined 80.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.8586 per EA |
|---|---|
| All-time high | $10.4335 (Jul 15, 2015) |
| All-time low | $1.6445 (Nov 20, 2024) |
| 52-week high | $2.2706 |
| 52-week low | $1.7078 |
| Median price | $5.4063 |
| Average price | $5.6107 |
| Largest weekly change | +60.0% (Jan 18, 2023) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the promethazine hydrochloride market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHEGAN 12.5 MG SUPPOS?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHEGAN 12.5 MG SUPPOS, manufactured by Cosette Pharmaceuticals, Inc., is $1.8586 per EA (NDC 00713053612), effective Aug 19, 2026.
How has the price of PROMETHEGAN 12.5 MG SUPPOS changed over time?
Over the history we have for it, the NADAC for PROMETHEGAN 12.5 MG SUPPOS has declined 80.1%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROMETHEGAN 12.5 MG SUPPOS?
Since Nov 28, 2013, the NADAC for PROMETHEGAN 12.5 MG SUPPOS has ranged from a low of $1.6445 (Nov 20, 2024) to a high of $10.4335 (Jul 15, 2015), with a median of $5.4063 per EA.
Are there cheaper alternatives to PROMETHEGAN 12.5 MG SUPPOS?
No other NADAC-published product currently shares the active ingredient and strength of PROMETHEGAN 12.5 MG SUPPOS in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PROMETHEGAN 12.5 MG SUPPOS?
PROMETHEGAN 12.5 MG SUPPOS (NDC 00713053612) is labeled by Cosette Pharmaceuticals, Inc., and CMS classifies it as a generic product.