Promethazine Hydrochloride
51 NDCs across 19 manufacturers|51 Generic,0 Brand
Promethazine Hydrochloride is used to treat anaphylaxis, allergic conjunctivitis, motion sickness, nausea, pain and postoperative complications, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 25 AB-rated (therapeutically equivalent) products for this ingredient.
Promethazine Hydrochloride is available as 51 NDCs from 19 manufacturers (51 generic, 0 brand), with NADAC prices from $0.04 to $26.69 per EA — the most expensive product costs about 638× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Active FDA drug shortage
10 Promethazine Hydrochloride presentations are currently listed in FDA's drug shortage database (first posted Nov 21, 2023). Shortages can move NADAC prices in the following weeks.
Total NDCs
51
51G / 0B
Manufacturers
19
competing in market
Price Spread
$0.04 – $26.69
per EA, 36 of 51 NDCs
7d Activity
avg +0.8% WoW · of 51 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Hikma Pharmaceuticals USA Inc. manufacturer profile
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Lead class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
19 manufacturers producing PROMETHAZINE HYDROCHLORIDE(1 pricing outlier)
Frequently Asked Questions
What is Promethazine Hydrochloride used to treat?
Promethazine Hydrochloride is used to treat anaphylaxis, allergic conjunctivitis, motion sickness, nausea, pain and postoperative complications, per the National Library of Medicine's MED-RT classification.
When did Promethazine Hydrochloride become available as a generic?
FDA approved the first generic Promethazine Hydrochloride (ANDA) on Jan 1, 1982. The Orange Book currently lists 25 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
Is Promethazine Hydrochloride in shortage?
Yes — FDA's drug shortage database currently lists 10 Promethazine Hydrochloride presentations with status "Current", first posted Nov 21, 2023.
How many Promethazine Hydrochloride products are on the market?
The Promethazine Hydrochloride drug market contains 51 NDCs from 19 manufacturers — 51 generic and 0 brand products.
What is the price range for Promethazine Hydrochloride?
NADAC reference prices for Promethazine Hydrochloride range from $0.0418 to $26.6913 per EA — the most expensive product costs about 638× the cheapest. 15 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Which manufacturers make Promethazine Hydrochloride?
19 manufacturers list Promethazine Hydrochloride in NADAC. Ranked by number of NDCs, the largest are Hikma Pharmaceuticals USA Inc. (7), Zydus Pharmaceuticals (USA) Inc. (5), KVK-Tech Inc. (5), Cosette Pharmaceuticals, Inc. (4), Amneal Pharmaceuticals LLC (4).
How has the price of Promethazine Hydrochloride changed recently?
Over the past 7 days, 30 Promethazine Hydrochloride NDCs rose and 14 fell, with a market-wide average change of +0.8%.