Product Information
PROMETHAZINE 6.25 MG/5 ML SOLN is a generic product labeled by PAI Holdings LLC, priced at $0.0422 per ML under NDC 00121185416. Its NADAC has been published 52 times since Aug 27, 2025.
FDA first approved this application on Apr 26, 2006. Its Orange Book therapeutic-equivalence code is AA.
Strength
6.25 mg/5mL
Manufacturer
PAI Holdings LLCNDC
00121185416
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040643FDA Approved
4/26/2006
TE Code
AA
On Market Since
8/7/2025
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 6.25 MG/5 ML SOLN has been published 52 times since Aug 27, 2025, and over the history we have for it it has risen 2.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0422 per ML |
|---|---|
| All-time high | $0.0446 (Nov 12, 2025) |
| All-time low | $0.0410 (Sep 17, 2025) |
| 52-week high | $0.0446 |
| 52-week low | $0.0410 |
| Median price | $0.0418 |
| Average price | $0.0424 |
| Largest weekly change | +8.9% (Oct 22, 2025) |
| Weeks tracked | 52 |
| Tracking since | Aug 27, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHAZINE 6.25 MG/5 ML SOLN?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 6.25 MG/5 ML SOLN, manufactured by PAI Holdings LLC, is $0.0422 per ML (NDC 00121185416), effective Aug 19, 2026.
How has the price of PROMETHAZINE 6.25 MG/5 ML SOLN changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 6.25 MG/5 ML SOLN has risen 2.2%. It has been tracked across 52 weekly CMS publications since Aug 27, 2025.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 6.25 MG/5 ML SOLN?
Since Aug 27, 2025, the NADAC for PROMETHAZINE 6.25 MG/5 ML SOLN has ranged from a low of $0.0410 (Sep 17, 2025) to a high of $0.0446 (Nov 12, 2025), with a median of $0.0418 per ML.
Are there cheaper alternatives to PROMETHAZINE 6.25 MG/5 ML SOLN?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE 6.25 MG/5 ML SOLN in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHAZINE 6.25 MG/5 ML SOLN?
PROMETHAZINE 6.25 MG/5 ML SOLN (NDC 00121185416) is labeled by PAI Holdings LLC, and CMS classifies it as a generic product.