Product Information
TRETINOIN 0.025% CREAM is a generic product labeled by NorthStar Rx LLC, priced at $0.5529 per GM under NDC 16714027001. Its NADAC has been published 100 times since Nov 6, 2024.
FDA first approved this application on Jan 5, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/g
Manufacturer
NorthStar Rx LLCNDC
16714027001
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA215713FDA Approved
1/5/2023
TE Code
AB
On Market Since
1/5/2023
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.025% CREAM has been published 100 times since Nov 6, 2024, and over the history we have for it it has declined 39.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5529 per GM |
|---|---|
| All-time high | $1.0981 (Sep 10, 2025) |
| All-time low | $0.5529 (Sep 23, 2026) |
| 52-week high | $1.0656 |
| 52-week low | $0.5529 |
| Median price | $0.8304 |
| Average price | $0.8429 |
| Largest weekly change | -16.1% (May 20, 2026) |
| Weeks tracked | 100 |
| Tracking since | Nov 6, 2024 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 17% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
NorthStar Rx LLC manufacturer profile
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Drug market
tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.025% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.025% CREAM, manufactured by NorthStar Rx LLC, is $0.5529 per GM (NDC 16714027001), effective Sep 30, 2026.
How has the price of TRETINOIN 0.025% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.025% CREAM has declined 39.9%. It has been tracked across 100 weekly CMS publications since Nov 6, 2024.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.025% CREAM?
Since Nov 6, 2024, the NADAC for TRETINOIN 0.025% CREAM has ranged from a low of $0.5529 (Sep 23, 2026) to a high of $1.0981 (Sep 10, 2025), with a median of $0.8304 per GM.
Are there cheaper alternatives to TRETINOIN 0.025% CREAM?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.025% CREAM, is $0.4593 per GM — about 17% below TRETINOIN 0.025% CREAM.
Who manufactures TRETINOIN 0.025% CREAM?
TRETINOIN 0.025% CREAM (NDC 16714027001) is labeled by NorthStar Rx LLC, and CMS classifies it as a generic product.