This NDC is on FDA's drug shortage list (posted Nov 21, 2023)
Product Information
PROMETHAZINE 25 MG/ML AMPUL is a generic product labeled by XGen Pharmaceuticals DJB, Inc., priced at $1.3345 per ML under NDC 39822552503. Its NADAC has been published 176 times since Sep 22, 2021.
FDA first approved this application on Apr 24, 2008. Its Orange Book therapeutic-equivalence code is AP.
Strength
25 mg/mL
Manufacturer
XGen Pharmaceuticals DJB, Inc.NDC
39822552503
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS
Effective Date
9/23/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040737FDA Approved
4/24/2008
TE Code
AP
On Market Since
1/30/2015
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 25 MG/ML AMPUL has been published 176 times since Sep 22, 2021, and over the history we have for it it has declined 25.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.3345 per ML |
|---|---|
| All-time high | $1.7806 (Sep 14, 2022) |
| All-time low | $1.2697 (Jul 22, 2026) |
| 52-week high | $1.6534 |
| 52-week low | $1.2697 |
| Median price | $1.5965 |
| Average price | $1.5881 |
| Largest weekly change | -11.8% (May 22, 2024) |
| Weeks tracked | 176 |
| Tracking since | Sep 22, 2021 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the PROMETHAZINE HYDROCHLORIDE market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
XGen Pharmaceuticals DJB, Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
PROMETHAZINE HYDROCHLORIDE market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE 25 MG/ML AMPUL?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 25 MG/ML AMPUL, manufactured by XGen Pharmaceuticals DJB, Inc., is $1.3345 per ML (NDC 39822552503), effective Sep 30, 2026.
How has the price of PROMETHAZINE 25 MG/ML AMPUL changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 25 MG/ML AMPUL has declined 25.1%. It has been tracked across 176 weekly CMS publications since Sep 22, 2021.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 25 MG/ML AMPUL?
Since Sep 22, 2021, the NADAC for PROMETHAZINE 25 MG/ML AMPUL has ranged from a low of $1.2697 (Jul 22, 2026) to a high of $1.7806 (Sep 14, 2022), with a median of $1.5965 per ML.
Are there cheaper alternatives to PROMETHAZINE 25 MG/ML AMPUL?
No other NADAC-published product currently shares the active ingredient and strength of PROMETHAZINE 25 MG/ML AMPUL in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PROMETHAZINE 25 MG/ML AMPUL?
PROMETHAZINE 25 MG/ML AMPUL (NDC 39822552503) is labeled by XGen Pharmaceuticals DJB, Inc., and CMS classifies it as a generic product.
Is PROMETHAZINE 25 MG/ML AMPUL in shortage?
Yes — NDC 39822552503 is currently listed in FDA's drug shortage database (posted Nov 21, 2023).