This NDC is on FDA's drug shortage list (posted Nov 21, 2023)
Reported reason: Demand increase for the drug
Product Information
PROMETHAZINE 50 MG/ML AMPUL is a generic product labeled by XGen Pharmaceuticals DJB, Inc., priced at $2.3389 per ML under NDC 39822555006. Its NADAC has been published 123 times since Apr 17, 2024.
FDA first approved this application on Apr 24, 2008. Its Orange Book therapeutic-equivalence code is AP.
Strength
50 mg/mL
Manufacturer
XGen Pharmaceuticals DJB, Inc.NDC
39822555006
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS
Effective Date
5/20/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040737FDA Approved
4/24/2008
TE Code
AP
On Market Since
1/30/2015
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 50 MG/ML AMPUL has been published 123 times since Apr 17, 2024, and over the history we have for it it has declined 11.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.3389 per ML |
|---|---|
| All-time high | $2.6483 (Jun 12, 2024) |
| All-time low | $2.2522 (May 21, 2025) |
| 52-week high | $2.3797 |
| 52-week low | $2.3015 |
| Median price | $2.3573 |
| Average price | $2.4010 |
| Largest weekly change | -7.3% (Oct 23, 2024) |
| Weeks tracked | 123 |
| Tracking since | Apr 17, 2024 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the PROMETHAZINE HYDROCHLORIDE market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHAZINE 50 MG/ML AMPUL?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 50 MG/ML AMPUL, manufactured by XGen Pharmaceuticals DJB, Inc., is $2.3389 per ML (NDC 39822555006), effective Aug 19, 2026.
How has the price of PROMETHAZINE 50 MG/ML AMPUL changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 50 MG/ML AMPUL has declined 11.7%. It has been tracked across 123 weekly CMS publications since Apr 17, 2024.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 50 MG/ML AMPUL?
Since Apr 17, 2024, the NADAC for PROMETHAZINE 50 MG/ML AMPUL has ranged from a low of $2.2522 (May 21, 2025) to a high of $2.6483 (Jun 12, 2024), with a median of $2.3573 per ML.
Are there cheaper alternatives to PROMETHAZINE 50 MG/ML AMPUL?
No other NADAC-published product currently shares the active ingredient and strength of PROMETHAZINE 50 MG/ML AMPUL in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PROMETHAZINE 50 MG/ML AMPUL?
PROMETHAZINE 50 MG/ML AMPUL (NDC 39822555006) is labeled by XGen Pharmaceuticals DJB, Inc., and CMS classifies it as a generic product.
Is PROMETHAZINE 50 MG/ML AMPUL in shortage?
Yes — NDC 39822555006 is currently listed in FDA's drug shortage database (posted Nov 21, 2023). Reported reason: Demand increase for the drug.