This NDC is on FDA's drug shortage list (posted Nov 21, 2023)
Reported reason: Demand increase for the drug
Product Information
PROMETHAZINE 50 MG/ML AMPUL is a generic product labeled by XGen Pharmaceuticals DJB, Inc., priced at $2.3389 per ML under NDC 39822555006. Its NADAC has been published 129 times since Apr 17, 2024.
FDA first approved this application on Apr 24, 2008. Its Orange Book therapeutic-equivalence code is AP.
Strength
50 mg/mL
Manufacturer
XGen Pharmaceuticals DJB, Inc.NDC
39822555006
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS
Effective Date
5/20/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040737FDA Approved
4/24/2008
TE Code
AP
On Market Since
1/30/2015
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 50 MG/ML AMPUL has been published 129 times since Apr 17, 2024, and over the history we have for it it has declined 11.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.3389 per ML |
|---|---|
| All-time high | $2.6483 (Jun 12, 2024) |
| All-time low | $2.2522 (May 21, 2025) |
| 52-week high | $2.3797 |
| 52-week low | $2.3015 |
| Median price | $2.3573 |
| Average price | $2.3981 |
| Largest weekly change | -7.3% (Oct 23, 2024) |
| Weeks tracked | 129 |
| Tracking since | Apr 17, 2024 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the PROMETHAZINE HYDROCHLORIDE market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
XGen Pharmaceuticals DJB, Inc. manufacturer profile
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Drug market
PROMETHAZINE HYDROCHLORIDE market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE 50 MG/ML AMPUL?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 50 MG/ML AMPUL, manufactured by XGen Pharmaceuticals DJB, Inc., is $2.3389 per ML (NDC 39822555006), effective Sep 30, 2026.
How has the price of PROMETHAZINE 50 MG/ML AMPUL changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 50 MG/ML AMPUL has declined 11.7%. It has been tracked across 129 weekly CMS publications since Apr 17, 2024.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 50 MG/ML AMPUL?
Since Apr 17, 2024, the NADAC for PROMETHAZINE 50 MG/ML AMPUL has ranged from a low of $2.2522 (May 21, 2025) to a high of $2.6483 (Jun 12, 2024), with a median of $2.3573 per ML.
Are there cheaper alternatives to PROMETHAZINE 50 MG/ML AMPUL?
No other NADAC-published product currently shares the active ingredient and strength of PROMETHAZINE 50 MG/ML AMPUL in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PROMETHAZINE 50 MG/ML AMPUL?
PROMETHAZINE 50 MG/ML AMPUL (NDC 39822555006) is labeled by XGen Pharmaceuticals DJB, Inc., and CMS classifies it as a generic product.
Is PROMETHAZINE 50 MG/ML AMPUL in shortage?
Yes — NDC 39822555006 is currently listed in FDA's drug shortage database (posted Nov 21, 2023). Reported reason: Demand increase for the drug.