Doxepin Hydrochloride
Brand names: Silenor, Sinequan
126 NDCs across 23 manufacturers|120 Generic,6 Brand
Doxepin is a tricyclic antidepressant with two very different lives: higher-dose capsules (formerly Sinequan) for depression and anxiety, and low-dose 3/6 mg tablets (Silenor) for insomnia maintenance. A topical cream form treats itching. Because the insomnia-strength tablets and the old generic capsules are separate product families, per-unit prices in this market fall into distinct tiers rather than one continuum.
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Doxepin Hydrochloride is used to treat anxiety disorders, depressive disorder, atopic dermatitis, pain and pruritus, per the National Library of Medicine's MED-RT classification. The brand product was first FDA-approved before 1982, and the first generic was approved May 13, 1986. FDA's Orange Book lists 91 AB-rated (therapeutically equivalent) products for this ingredient.
Doxepin Hydrochloride is available as 126 NDCs from 23 manufacturers (120 generic, 6 brand), with NADAC prices from $0.07 to $17.32 per EA — the most expensive product costs about 235× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
126
120G / 6B
Manufacturers
23
competing in market
Price Spread
$0.07 – $17.32
per EA, 122 of 126 NDCs
7d Activity
avg +4.0% WoW · of 126 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Mylan Pharmaceuticals Inc. manufacturer profile
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Lead class
Tricyclic Antidepressant class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
23 manufacturers producing DOXEPIN HYDROCHLORIDE(2 pricing outliers)
Frequently Asked Questions
What is Doxepin Hydrochloride used to treat?
Doxepin Hydrochloride is used to treat anxiety disorders, depressive disorder, atopic dermatitis, pain and pruritus, per the National Library of Medicine's MED-RT classification.
When did Doxepin Hydrochloride become available as a generic?
FDA approved the first generic Doxepin Hydrochloride (ANDA) on May 13, 1986. The Orange Book currently lists 91 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How many Doxepin Hydrochloride products are on the market?
The Doxepin Hydrochloride drug market contains 126 NDCs from 23 manufacturers — 120 generic and 6 brand products.
What is the price range for Doxepin Hydrochloride?
NADAC reference prices for Doxepin Hydrochloride range from $0.0738 to $17.3225 per EA — the most expensive product costs about 235× the cheapest. 4 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Is generic Doxepin Hydrochloride cheaper than brand?
The average generic NADAC for Doxepin Hydrochloride is $0.3539 per EA, versus $13.7038 for brand-labeled products — brand versions average about 39× the generic price.
Which manufacturers make Doxepin Hydrochloride?
23 manufacturers list Doxepin Hydrochloride in NADAC. Ranked by number of NDCs, the largest are Mylan Pharmaceuticals Inc. (11), PuraCap Laboratories LLC (11), Amneal Pharmaceuticals NY LLC (10), Ajanta Pharma USA Inc. (10), Currax Pharmaceuticals LLC (8).
How has the price of Doxepin Hydrochloride changed recently?
Over the past 7 days, 90 Doxepin Hydrochloride NDCs rose and 6 fell, with a market-wide average change of +4.0%.