Hydrochlorothiazide
71 NDCs across 17 manufacturers|70 Generic,1 Brand
Hydrochlorothiazide is used to treat edema, heart failure, hypertension and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 28 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $81 million on Hydrochlorothiazide across 18.5 million claims for 4.9 million beneficiaries.
Hydrochlorothiazide is available as 71 NDCs from 17 manufacturers (70 generic, 1 brand), with NADAC prices from $0.01 to $0.04 per EA — the most expensive product costs about 3.8× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
71
70G / 1B
Manufacturers
17
competing in market
Price Spread
$0.01 – $0.04
per EA, 70 of 71 NDCs
7d Activity
avg -1.8% WoW · of 71 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Explore this market from other angles
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Top supplier
Unichem Pharmaceuticals (USA) Inc. manufacturer profile
Open the supplier page for the manufacturer with the strongest footprint in this market.
Lead class
Thiazide Diuretic class view
See how this market rolls up into the broader therapeutic class and compare other drugs in the same bucket.
Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
17 manufacturers producing HYDROCHLOROTHIAZIDE(2 pricing outliers)
Frequently Asked Questions
What is Hydrochlorothiazide used to treat?
Hydrochlorothiazide is used to treat edema, heart failure, hypertension and nephrotic syndrome, per the National Library of Medicine's MED-RT classification.
When did Hydrochlorothiazide become available as a generic?
FDA approved the first generic Hydrochlorothiazide (ANDA) on Jan 1, 1982. The Orange Book currently lists 28 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Hydrochlorothiazide?
In 2024, Medicare Part D spent $81 million on Hydrochlorothiazide across 18.5 million claims for 4.9 million beneficiaries.
How many Hydrochlorothiazide products are on the market?
The Hydrochlorothiazide drug market contains 71 NDCs from 17 manufacturers — 70 generic and 1 brand product.
What is the price range for Hydrochlorothiazide?
NADAC reference prices for Hydrochlorothiazide range from $0.0115 to $0.0444 per EA — the most expensive product costs about 3.8× the cheapest. 1 additional product is priced per a different unit (e.g. liquids per ML) and isn't directly comparable.
Which manufacturers make Hydrochlorothiazide?
17 manufacturers list Hydrochlorothiazide in NADAC. Ranked by number of NDCs, the largest are Unichem Pharmaceuticals (USA) Inc. (9), Aurobindo Pharma Limited (6), Heritage Pharmaceuticals Inc. (6), Leading Pharma, LLC (6), Accord Healthcare Inc. (6).
How has the price of Hydrochlorothiazide changed recently?
Over the past 7 days, 19 Hydrochlorothiazide NDCs rose and 49 fell, with a market-wide average change of -1.8%.