Leucovorin Calcium
30 NDCs across 7 manufacturers|30 Generic,0 Brand
Leucovorin Calcium is used to treat megaloblastic anemia, drug-related side effects and adverse reactions and folic acid deficiency, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Oct 19, 1982. FDA's Orange Book lists 18 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $5 million on Leucovorin Calcium across 104,000 claims for 28,000 beneficiaries.
Leucovorin Calcium is available as 30 NDCs from 7 manufacturers (30 generic, 0 brand), with NADAC prices from $0.34 to $2.00 per EA — the most expensive product costs about 5.8× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
30
30G / 0B
Manufacturers
7
competing in market
Price Spread
$0.34 – $2.00
per EA
7d Activity
avg -4.3% WoW · of 30 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Hikma Pharmaceuticals USA Inc. manufacturer profile
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Lead class
Folate Analog class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
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Manufacturer Breakdown
7 manufacturers producing LEUCOVORIN CALCIUM
Frequently Asked Questions
What is Leucovorin Calcium used to treat?
Leucovorin Calcium is used to treat megaloblastic anemia, drug-related side effects and adverse reactions and folic acid deficiency, per the National Library of Medicine's MED-RT classification.
When did Leucovorin Calcium become available as a generic?
FDA approved the first generic Leucovorin Calcium (ANDA) on Oct 19, 1982. The Orange Book currently lists 18 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Leucovorin Calcium?
In 2024, Medicare Part D spent $5 million on Leucovorin Calcium across 104,000 claims for 28,000 beneficiaries.
How many Leucovorin Calcium products are on the market?
The Leucovorin Calcium drug market contains 30 NDCs from 7 manufacturers — 30 generic and 0 brand products.
What is the price range for Leucovorin Calcium?
NADAC reference prices for Leucovorin Calcium range from $0.3430 to $2.0009 per EA — the most expensive product costs about 5.8× the cheapest.
Which manufacturers make Leucovorin Calcium?
7 manufacturers list Leucovorin Calcium in NADAC. Ranked by number of NDCs, the largest are Hikma Pharmaceuticals USA Inc. (7), Ingenus Pharmaceuticals LLC (6), Epic Pharma LLC (6), Leading Pharma, LLC (6), Teva Pharmaceuticals USA Inc. (3).
How has the price of Leucovorin Calcium changed recently?
Over the past 7 days, 12 Leucovorin Calcium NDCs rose and 17 fell, with a market-wide average change of -4.3%.