This NDC is on FDA's drug shortage list (posted Nov 21, 2023)
Reported reason: Other
Product Information
PROMETHAZINE 50 MG/ML AMPUL is a generic product labeled by Hikma Pharmaceuticals USA Inc., priced at $2.3389 per ML under NDC 00641149635. Its NADAC has been published 252 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AP.
Strength
50 mg/mL
Manufacturer
Hikma Pharmaceuticals USA Inc.NDC
00641149635
Classification
Generic
Dosage Form
INJECTION
Route
INTRAMUSCULAR
Effective Date
5/20/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA083312FDA Approved
Before 1982
TE Code
AP
On Market Since
9/19/1973
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 50 MG/ML AMPUL has been published 252 times since Nov 28, 2013, and over the history we have for it it has risen 26.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.3389 per ML |
|---|---|
| All-time high | $2.7026 (May 11, 2016) |
| All-time low | $1.6499 (Dec 18, 2013) |
| 52-week high | $2.3797 |
| 52-week low | $2.3015 |
| Median price | $2.3495 |
| Average price | $2.2906 |
| Largest weekly change | +50.0% (Apr 22, 2015) |
| Weeks tracked | 252 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHAZINE 50 MG/ML AMPUL?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 50 MG/ML AMPUL, manufactured by Hikma Pharmaceuticals USA Inc., is $2.3389 per ML (NDC 00641149635), effective Aug 19, 2026.
How has the price of PROMETHAZINE 50 MG/ML AMPUL changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 50 MG/ML AMPUL has risen 26.3%. It has been tracked across 252 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 50 MG/ML AMPUL?
Since Nov 28, 2013, the NADAC for PROMETHAZINE 50 MG/ML AMPUL has ranged from a low of $1.6499 (Dec 18, 2013) to a high of $2.7026 (May 11, 2016), with a median of $2.3495 per ML.
Are there cheaper alternatives to PROMETHAZINE 50 MG/ML AMPUL?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE 50 MG/ML AMPUL in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHAZINE 50 MG/ML AMPUL?
PROMETHAZINE 50 MG/ML AMPUL (NDC 00641149635) is labeled by Hikma Pharmaceuticals USA Inc., and CMS classifies it as a generic product.
Is PROMETHAZINE 50 MG/ML AMPUL in shortage?
Yes — NDC 00641149635 is currently listed in FDA's drug shortage database (posted Nov 21, 2023). Reported reason: Other.