Product Information
PROMETHAZINE 25 MG/ML VIAL is a generic product labeled by Hikma Pharmaceuticals USA Inc., priced at $1.7483 per ML under NDC 00641620825. Its NADAC has been published 237 times since Jul 25, 2018.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AP.
Strength
25 mg/mL
Manufacturer
Hikma Pharmaceuticals USA Inc.NDC
00641620825
Classification
Generic
Dosage Form
INJECTION
Route
INTRAMUSCULAR; INTRAVENOUS
Effective Date
9/23/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA083312FDA Approved
Before 1982
TE Code
AP
On Market Since
9/19/1973
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 25 MG/ML VIAL has been published 237 times since Jul 25, 2018, and over the history we have for it it has risen 60.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.7483 per ML |
|---|---|
| All-time high | $1.7691 (Apr 15, 2026) |
| All-time low | $1.0267 (Sep 19, 2018) |
| 52-week high | $1.7691 |
| 52-week low | $1.7321 |
| Median price | $1.7081 |
| Average price | $1.5437 |
| Largest weekly change | +63.9% (Mar 17, 2021) |
| Weeks tracked | 237 |
| Tracking since | Jul 25, 2018 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 24% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Hikma Pharmaceuticals USA Inc. manufacturer profile
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Drug market
Promethazine Hydrochloride market comparison
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Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE 25 MG/ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 25 MG/ML VIAL, manufactured by Hikma Pharmaceuticals USA Inc., is $1.7483 per ML (NDC 00641620825), effective Sep 30, 2026.
How has the price of PROMETHAZINE 25 MG/ML VIAL changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 25 MG/ML VIAL has risen 60.9%. It has been tracked across 237 weekly CMS publications since Jul 25, 2018.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 25 MG/ML VIAL?
Since Jul 25, 2018, the NADAC for PROMETHAZINE 25 MG/ML VIAL has ranged from a low of $1.0267 (Sep 19, 2018) to a high of $1.7691 (Apr 15, 2026), with a median of $1.7081 per ML.
Are there cheaper alternatives to PROMETHAZINE 25 MG/ML VIAL?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, PROMETHAZINE 25 MG/ML AMPUL, is $1.3345 per ML — about 24% below PROMETHAZINE 25 MG/ML VIAL.
Who manufactures PROMETHAZINE 25 MG/ML VIAL?
PROMETHAZINE 25 MG/ML VIAL (NDC 00641620825) is labeled by Hikma Pharmaceuticals USA Inc., and CMS classifies it as a generic product.