Product Information
METHOTREXATE 2.5 MG TABLET is a generic product labeled by Accord Healthcare Inc., priced at $0.1577 per EA under NDC 16729048601. Its NADAC has been published 312 times since Oct 14, 2020.
FDA first approved this application on Jan 24, 2020. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2.5 mg/1
Manufacturer
Accord Healthcare Inc.NDC
16729048601
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
METHOTREXATE SODIUMApproval Type
Generic (ANDA)
FDA Application
ANDA213343FDA Approved
1/24/2020
TE Code
AB
On Market Since
8/24/2020
Pharmacological Classes
Price Statistics
The NADAC for METHOTREXATE 2.5 MG TABLET has been published 312 times since Oct 14, 2020, and over the history we have for it it has declined 60.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1577 per EA |
|---|---|
| All-time high | $0.5061 (Mar 10, 2021) |
| All-time low | $0.1507 (May 22, 2024) |
| 52-week high | $0.1645 |
| 52-week low | $0.1530 |
| Median price | $0.1953 |
| Average price | $0.2352 |
| Largest weekly change | +41.4% (Jun 19, 2024) |
| Weeks tracked | 312 |
| Tracking since | Oct 14, 2020 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Accord Healthcare Inc. manufacturer profile
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Drug market
Methotrexate market comparison
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Therapeutic class
Folate Analog Metabolic Inhibitor class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of METHOTREXATE 2.5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for METHOTREXATE 2.5 MG TABLET, manufactured by Accord Healthcare Inc., is $0.1577 per EA (NDC 16729048601), effective Sep 30, 2026.
How has the price of METHOTREXATE 2.5 MG TABLET changed over time?
Over the history we have for it, the NADAC for METHOTREXATE 2.5 MG TABLET has declined 60.9%. It has been tracked across 312 weekly CMS publications since Oct 14, 2020.
What are the highest and lowest recorded NADAC prices for METHOTREXATE 2.5 MG TABLET?
Since Oct 14, 2020, the NADAC for METHOTREXATE 2.5 MG TABLET has ranged from a low of $0.1507 (May 22, 2024) to a high of $0.5061 (Mar 10, 2021), with a median of $0.1953 per EA.
Are there cheaper alternatives to METHOTREXATE 2.5 MG TABLET?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as METHOTREXATE 2.5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures METHOTREXATE 2.5 MG TABLET?
METHOTREXATE 2.5 MG TABLET (NDC 16729048601) is labeled by Accord Healthcare Inc., and CMS classifies it as a generic product.