Product Information
METHOTREXATE 2.5 MG TABLET is a generic product labeled by Zydus Pharmaceuticals (USA) Inc., priced at $0.1566 per EA under NDC 68382077501. Its NADAC has been published 489 times since Apr 12, 2017.
FDA first approved this application on Jan 13, 2017. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2.5 mg/1
Manufacturer
Zydus Pharmaceuticals (USA) Inc.NDC
68382077501
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
METHOTREXATEApproval Type
Generic (ANDA)
FDA Application
ANDA207812FDA Approved
1/13/2017
TE Code
AB
On Market Since
2/9/2017
Pharmacological Classes
Price Statistics
The NADAC for METHOTREXATE 2.5 MG TABLET has been published 489 times since Apr 12, 2017, and over the history we have for it it has declined 86.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1566 per EA |
|---|---|
| All-time high | $1.1166 (Apr 12, 2017) |
| All-time low | $0.1507 (May 22, 2024) |
| 52-week high | $0.1694 |
| 52-week low | $0.1530 |
| Median price | $0.3019 |
| Average price | $0.4071 |
| Largest weekly change | +41.4% (Jun 19, 2024) |
| Weeks tracked | 489 |
| Tracking since | Apr 12, 2017 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHOTREXATE 2.5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for METHOTREXATE 2.5 MG TABLET, manufactured by Zydus Pharmaceuticals (USA) Inc., is $0.1566 per EA (NDC 68382077501), effective Aug 19, 2026.
How has the price of METHOTREXATE 2.5 MG TABLET changed over time?
Over the history we have for it, the NADAC for METHOTREXATE 2.5 MG TABLET has declined 86.0%. It has been tracked across 489 weekly CMS publications since Apr 12, 2017.
What are the highest and lowest recorded NADAC prices for METHOTREXATE 2.5 MG TABLET?
Since Apr 12, 2017, the NADAC for METHOTREXATE 2.5 MG TABLET has ranged from a low of $0.1507 (May 22, 2024) to a high of $1.1166 (Apr 12, 2017), with a median of $0.3019 per EA.
Are there cheaper alternatives to METHOTREXATE 2.5 MG TABLET?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as METHOTREXATE 2.5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures METHOTREXATE 2.5 MG TABLET?
METHOTREXATE 2.5 MG TABLET (NDC 68382077501) is labeled by Zydus Pharmaceuticals (USA) Inc., and CMS classifies it as a generic product.