Product Information
METHOTREXATE 2.5 MG TABLET is a generic product labeled by Teva Pharmaceuticals USA Inc., priced at $0.1566 per EA under NDC 00555057235. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application on Oct 15, 1990. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2.5 mg/1
Manufacturer
Teva Pharmaceuticals USA Inc.NDC
00555057235
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
METHOTREXATE SODIUMApproval Type
Generic (ANDA)
FDA Application
ANDA081099FDA Approved
10/15/1990
TE Code
AB
On Market Since
11/1/1990
Pharmacological Classes
Price Statistics
The NADAC for METHOTREXATE 2.5 MG TABLET has been published 665 times since Nov 28, 2013, and over the history we have for it it has declined 93.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1566 per EA |
|---|---|
| All-time high | $2.2433 (Dec 11, 2013) |
| All-time low | $0.1507 (May 22, 2024) |
| 52-week high | $0.1694 |
| 52-week low | $0.1530 |
| Median price | $0.5313 |
| Average price | $0.7395 |
| Largest weekly change | +41.4% (Jun 19, 2024) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of METHOTREXATE 2.5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for METHOTREXATE 2.5 MG TABLET, manufactured by Teva Pharmaceuticals USA Inc., is $0.1566 per EA (NDC 00555057235), effective Aug 19, 2026.
How has the price of METHOTREXATE 2.5 MG TABLET changed over time?
Over the history we have for it, the NADAC for METHOTREXATE 2.5 MG TABLET has declined 93.0%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for METHOTREXATE 2.5 MG TABLET?
Since Nov 28, 2013, the NADAC for METHOTREXATE 2.5 MG TABLET has ranged from a low of $0.1507 (May 22, 2024) to a high of $2.2433 (Dec 11, 2013), with a median of $0.5313 per EA.
Are there cheaper alternatives to METHOTREXATE 2.5 MG TABLET?
6 manufacturers publish a NADAC-priced product with the same active ingredient and strength as METHOTREXATE 2.5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures METHOTREXATE 2.5 MG TABLET?
METHOTREXATE 2.5 MG TABLET (NDC 00555057235) is labeled by Teva Pharmaceuticals USA Inc., and CMS classifies it as a generic product.