Spironolactone

91 NDCs across 18 manufacturers|90 Generic,1 Brand

Spironolactone is used to treat ascites, edema, heart failure, hirsutism, hyperaldosteronism and hypertension, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved on Dec 30, 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 36 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $81 million on Spironolactone across 9.1 million claims for 2.4 million beneficiaries.

Spironolactone is available as 91 NDCs from 18 manufacturers (90 generic, 1 brand), with NADAC prices from $0.04 to $2.47 per EA — the most expensive product costs about 57× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

90G / 1B

Manufacturers

competing in market

Price Spread

$0.04 – $2.47

per EA, 85 of 91 NDCs

7d Activity

6↑66↓19 flat

avg -1.2% WoW · of 91 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

18 manufacturers producing SPIRONOLACTONE(4 pricing outliers)

Sun Pharmaceutical Industries Inc.

11 NDCs

$0.1149

avg/unit

Jubilant Cadista Pharmaceuticals Inc.

8 NDCs

$0.0859

avg/unit

Oxford Pharmaceuticals, LLC

8 NDCs

$0.0851

avg/unit

Accord Healthcare Inc.

7 NDCs

$0.0963

avg/unit

Zydus Pharmaceuticals (USA) Inc.

Amneal Pharmaceuticals of New York LLC

7 NDCs

$0.0912

avg/unit

Amneal Pharmaceuticals LLC

7 NDCs

$0.0899

avg/unit

Aurobindo Pharma Limited

6 NDCs

$0.0780

avg/unit

Camber Pharmaceuticals Inc.

Mylan Pharmaceuticals Inc.

5 NDCs

$0.0850

avg/unit

American Health Packaging

3 NDCs

$0.0992

avg/unit

Mylan Institutional LLC

3 NDCs

$0.0992

avg/unit

Amneal Pharmaceuticals NY LLC

Major Pharmaceuticals

1 NDC

$0.0430

avg/unit

Drug Portfolio

91 NDCs total, 91 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
ALDACTONE 25 MG TABLET	00025100131	Pfizer Inc.	$2.4713 per EA	High Outlier	Brand	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG/5 ML SUSP	69238202702	Amneal Pharmaceuticals NY LLC	$1.8338 per ML	High Outlier	Generic	+2.26%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG/5 ML SUSP	00574113316	Padagis US LLC	$1.8338 per ML	High Outlier	Generic	+2.26%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG/5 ML SUSP	31722069147	Camber Pharmaceuticals Inc.	$1.8338 per ML	High Outlier	Generic	+2.26%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG/5 ML SUSP	00574113304	Padagis US LLC	$1.5664 per ML	High Outlier	Generic	+2.28%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG/5 ML SUSP	31722069111	Camber Pharmaceuticals Inc.	$1.5664 per ML	High Outlier	Generic	+2.28%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG/5 ML SUSP	69238202708	Amneal Pharmaceuticals NY LLC	$1.5664 per ML	High Outlier	Generic	+2.28%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	53489032807	Sun Pharmaceutical Industries Inc.	$0.1967 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	16729022701	Accord Healthcare Inc.	$0.1784 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	16729022716	Accord Healthcare Inc.	$0.1784 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	68382066201	Zydus Pharmaceuticals (USA) Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	53489032901	Sun Pharmaceutical Industries Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	53489032905	Sun Pharmaceutical Industries Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	53489032906	Sun Pharmaceutical Industries Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	53489032907	Sun Pharmaceutical Industries Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	31722009605	Camber Pharmaceuticals Inc.	$0.1699 per EA	High Outlier	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	59651042801	Aurobindo Pharma Limited	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	72603013602	NorthStar Rx LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	72603013601	NorthStar Rx LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	59746021801	Jubilant Cadista Pharmaceuticals Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	59746021806	Jubilant Cadista Pharmaceuticals Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	60687048701	American Health Packaging	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	51079098008	Mylan Institutional LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	69584085450	Oxford Pharmaceuticals, LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	69584085410	Oxford Pharmaceuticals, LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	53746051501	Amneal Pharmaceuticals of New York LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	53746051505	Amneal Pharmaceuticals of New York LLC	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	68382066205	Zydus Pharmaceuticals (USA) Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	00378043701	Mylan Pharmaceuticals Inc.	$0.1699 per EA	—	Generic	-2.65%	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	65162051510	Amneal Pharmaceuticals LLC	$0.1618 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 100 MG TABLET	65162051550	Amneal Pharmaceuticals LLC	$0.1618 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	16729022616	Accord Healthcare Inc.	$0.0893 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	16729022601	Accord Healthcare Inc.	$0.0893 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	53489032806	Sun Pharmaceutical Industries Inc.	$0.0891 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	65162051450	Amneal Pharmaceuticals LLC	$0.0853 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	65162051410	Amneal Pharmaceuticals LLC	$0.0853 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	59651042705	Aurobindo Pharma Limited	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	00378024305	Mylan Pharmaceuticals Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	00378024301	Mylan Pharmaceuticals Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	31722009505	Camber Pharmaceuticals Inc.	$0.0846 per EA	High Outlier	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	51079097920	Mylan Institutional LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	53489032801	Sun Pharmaceutical Industries Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	53489032805	Sun Pharmaceutical Industries Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	53746051401	Amneal Pharmaceuticals of New York LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	53746051405	Amneal Pharmaceuticals of New York LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	59651042701	Aurobindo Pharma Limited	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	69584085310	Oxford Pharmaceuticals, LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	59746021701	Jubilant Cadista Pharmaceuticals Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	59746021706	Jubilant Cadista Pharmaceuticals Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	72603013502	NorthStar Rx LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	60687047601	American Health Packaging	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	72603013501	NorthStar Rx LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	68382066101	Zydus Pharmaceuticals (USA) Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	68382066105	Zydus Pharmaceuticals (USA) Inc.	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 50 MG TABLET	69584085350	Oxford Pharmaceuticals, LLC	$0.0846 per EA	—	Generic	-1.56%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	16729022517	Accord Healthcare Inc.	$0.0494 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59746021601	Jubilant Cadista Pharmaceuticals Inc.	$0.0494 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	63739054410	McKesson	$0.0458 per EA	Low Outlier	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	65162051110	Amneal Pharmaceuticals LLC	$0.0452 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	65162051150	Amneal Pharmaceuticals LLC	$0.0452 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	65162051111	Amneal Pharmaceuticals LLC	$0.0452 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	16729022516	Accord Healthcare Inc.	$0.0447 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	16729022501	Accord Healthcare Inc.	$0.0447 per EA	—	Generic	—	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	68382066010	Zydus Pharmaceuticals (USA) Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	68382066005	Zydus Pharmaceuticals (USA) Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	72603013401	NorthStar Rx LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	72603013402	NorthStar Rx LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	72603013403	NorthStar Rx LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	68382066001	Zydus Pharmaceuticals (USA) Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	60687046501	American Health Packaging	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59746021609	Jubilant Cadista Pharmaceuticals Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59746021606	Jubilant Cadista Pharmaceuticals Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59746021605	Jubilant Cadista Pharmaceuticals Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	00378214605	Mylan Pharmaceuticals Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59651042699	Aurobindo Pharma Limited	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59651042605	Aurobindo Pharma Limited	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	59651042601	Aurobindo Pharma Limited	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	53746051110	Amneal Pharmaceuticals of New York LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	53746051105	Amneal Pharmaceuticals of New York LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	53746051101	Amneal Pharmaceuticals of New York LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	53489014310	Sun Pharmaceutical Industries Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	00378214601	Mylan Pharmaceuticals Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	53489014305	Sun Pharmaceutical Industries Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	53489014301	Sun Pharmaceutical Industries Inc.	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	51079010320	Mylan Institutional LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	31722009410	Camber Pharmaceuticals Inc.	$0.0430 per EA	High Outlier	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	00904692761	Major Pharmaceuticals	$0.0430 per EA	Low Outlier	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	69584085290	Oxford Pharmaceuticals, LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	69584085250	Oxford Pharmaceuticals, LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	69584085292	Oxford Pharmaceuticals, LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist
SPIRONOLACTONE 25 MG TABLET	69584085210	Oxford Pharmaceuticals, LLC	$0.0430 per EA	—	Generic	-0.67%	Aldosterone Antagonist

Frequently Asked Questions

What is Spironolactone used to treat?

Spironolactone is used to treat ascites, edema, heart failure, hirsutism, hyperaldosteronism and hypertension, per the National Library of Medicine's MED-RT classification.

When did Spironolactone become available as a generic?

FDA approved the first generic Spironolactone (ANDA) on Jan 1, 1982. The Orange Book currently lists 36 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Spironolactone?

In 2024, Medicare Part D spent $81 million on Spironolactone across 9.1 million claims for 2.4 million beneficiaries.

How many Spironolactone products are on the market?

The Spironolactone drug market contains 91 NDCs from 18 manufacturers — 90 generic and 1 brand product.

What is the price range for Spironolactone?

NADAC reference prices for Spironolactone range from $0.0430 to $2.4713 per EA — the most expensive product costs about 57× the cheapest. 6 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Is generic Spironolactone cheaper than brand?

The average generic NADAC for Spironolactone is $0.0920 per EA, versus $2.4713 for brand-labeled products — brand versions average about 27× the generic price.

Which manufacturers make Spironolactone?

18 manufacturers list Spironolactone in NADAC. Ranked by number of NDCs, the largest are Sun Pharmaceutical Industries Inc. (11), Jubilant Cadista Pharmaceuticals Inc. (8), Oxford Pharmaceuticals, LLC (8), Accord Healthcare Inc. (7), Zydus Pharmaceuticals (USA) Inc. (7).

How has the price of Spironolactone changed recently?

Over the past 7 days, 6 Spironolactone NDCs rose and 66 fell, with a market-wide average change of -1.2%.