Product Information
PROMETHEGAN 25 MG SUPPOSITORY is a generic product labeled by Cosette Pharmaceuticals, Inc., priced at $2.0438 per EA under NDC 00713052612. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application on Feb 5, 2002. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Promethazine Hydrochloride market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25 mg/1
Manufacturer
Cosette Pharmaceuticals, Inc.NDC
00713052612
Classification
Generic
Dosage Form
SUPPOSITORY
Route
RECTAL
Effective Date
8/19/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040428FDA Approved
2/5/2002
TE Code
AB
On Market Since
2/28/2002
Pharmacological Classes
Price Statistics
The NADAC for PROMETHEGAN 25 MG SUPPOSITORY has been published 665 times since Nov 28, 2013, and over the history we have for it it has declined 75.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.0438 per EA |
|---|---|
| All-time high | $9.2294 (May 13, 2015) |
| All-time low | $1.8394 (Nov 20, 2024) |
| 52-week high | $2.1144 |
| 52-week low | $1.8404 |
| Median price | $4.8994 |
| Average price | $5.1897 |
| Largest weekly change | +42.4% (Jul 19, 2023) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHEGAN 25 MG SUPPOSITORY?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHEGAN 25 MG SUPPOSITORY, manufactured by Cosette Pharmaceuticals, Inc., is $2.0438 per EA (NDC 00713052612), effective Aug 19, 2026.
How has the price of PROMETHEGAN 25 MG SUPPOSITORY changed over time?
Over the history we have for it, the NADAC for PROMETHEGAN 25 MG SUPPOSITORY has declined 75.5%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROMETHEGAN 25 MG SUPPOSITORY?
Since Nov 28, 2013, the NADAC for PROMETHEGAN 25 MG SUPPOSITORY has ranged from a low of $1.8394 (Nov 20, 2024) to a high of $9.2294 (May 13, 2015), with a median of $4.8994 per EA.
Are there cheaper alternatives to PROMETHEGAN 25 MG SUPPOSITORY?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PROMETHEGAN 25 MG SUPPOSITORY in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHEGAN 25 MG SUPPOSITORY?
PROMETHEGAN 25 MG SUPPOSITORY (NDC 00713052612) is labeled by Cosette Pharmaceuticals, Inc., and CMS classifies it as a generic product.