Product Information
PROMETHAZINE 25 MG SUPPOSITORY is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $2.0348 per EA under NDC 45802075930. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Jun 30, 2003. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802075930
Classification
Generic
Dosage Form
SUPPOSITORY
Route
RECTAL
Effective Date
9/23/2026
Active Ingredients
PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040500FDA Approved
6/30/2003
TE Code
AB
On Market Since
5/17/2006
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE 25 MG SUPPOSITORY has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 75.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $2.0348 per EA |
|---|---|
| All-time high | $9.2294 (May 13, 2015) |
| All-time low | $1.8394 (Nov 20, 2024) |
| 52-week high | $2.1144 |
| 52-week low | $1.8404 |
| Median price | $4.8876 |
| Average price | $5.1616 |
| Largest weekly change | +42.4% (Jul 19, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
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Drug market
Promethazine Hydrochloride market comparison
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Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE 25 MG SUPPOSITORY?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE 25 MG SUPPOSITORY, manufactured by Padagis Israel Pharmaceuticals Ltd, is $2.0348 per EA (NDC 45802075930), effective Sep 30, 2026.
How has the price of PROMETHAZINE 25 MG SUPPOSITORY changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE 25 MG SUPPOSITORY has declined 75.6%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE 25 MG SUPPOSITORY?
Since Nov 28, 2013, the NADAC for PROMETHAZINE 25 MG SUPPOSITORY has ranged from a low of $1.8394 (Nov 20, 2024) to a high of $9.2294 (May 13, 2015), with a median of $4.8876 per EA.
Are there cheaper alternatives to PROMETHAZINE 25 MG SUPPOSITORY?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE 25 MG SUPPOSITORY in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHAZINE 25 MG SUPPOSITORY?
PROMETHAZINE 25 MG SUPPOSITORY (NDC 45802075930) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.